The Division of Neuroscience within the School of Biological Sciences, Faculty of Biology Medicine and Health wish to appoint a laboratory-based Research Assistant to an exciting project exploring how light and circadian mechanisms interact in the brain’s supraoptic nucleus to regulate daily rhythms and timing in the sleep and wake cycles. This BBSRC funded project offers a fantastic opportunity to be at the forefront of circadian and sleep neuroscience to understand how our sleep-wake cycles are regulated by light and circadian rhythm.
During this position, the post-holder will undertake a range of activities including the application of innovative approaches for brain circuit manipulation and mapping, in and ex vivo, with comprehensive physiological and behavioural measurements, both in mice and our powerful new day-active rodent model (Rhabdomys Pumillio). Collectively, we expect this exciting programme of work will drive a step-change in our understanding of the brain mechanisms responsible for daily and circadian control of the sleep-wake cycle and much-needed insights into how these mechanisms differ between nocturnal and diurnal mammals (like us).
The successful candidate will join a thriving neuroscience and circadian community. You will also benefit from regular interactions with members of the Time, Vision and Behaviour, an informal grouping of seven labs with common interests in light and circadian neuroscience, who share equipment and complementary skills, and the wider Centre for Biological Timing research community (https://sites.manchester.ac.uk/bio-timing/).
Start date is flexible, but we hope to have someone in post by March 2025, for a period of 36 months. Applicants are expected to have a good level of experience in a relevant branch of life sciences. Full training is available, however, the ability to work independently is essential, as is experience in and practical knowledge of neurophysiology. Experience with electrophysiological recording, preferably whole-cell patch clamp electrophysiology, and/or studies of visual or circadian function is highly desirable. Experience with laboratory rodents and relevant surgical procedures is also desirable.
Successful candidates may be subject to pre-employment screening carried out on our behalf by a third party. The offer of employment will be dependent on the successful candidate passing this screening. Whilst you will be required to provide express consent at a later stage, by continuing with your application now you acknowledge that you are aware that such screening will take place and agree to take part in the process.

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