RESEARCH ASSOCIATE I – MOLECULAR ANATOMY – ANTIBODY ENGINEERING

The mission of the Allen Institute is to unlock the complexities of bioscience and advance our knowledge to improve human health. Using an open science, multi-scale, team-oriented approach, the Allen Institute focuses on accelerating foundational research, developing standards and models, and cultivating new ideas to make a broad, transformational impact on science.
The mission of the Allen Institute for Neural Dynamics is focused on fundamental discoveries in systems neuroscience. We are interested in how the brain builds our understanding of the complex world to guide the flexible behaviors that address our biological needs. The answers will be in terms of defined neuron types and circuits interacting across the whole brain and body. We will develop next-generation methods and theories and employ a team-based approach to discovery neuroscience. Knowledge, data, models, and tools will be widely shared to support the development of therapies for brain disorders
We are seeking a Research Associate to contribute to efforts to engineer antibodies and other protein-binding proteins for tissue labeling. In recent years, there have been rapid advances in spatial transcriptomics (i.e. imaging of mRNA) but efforts to localize proteins have lagged far behind. By adopting and optimizing state-of-the-art expansion microscopy techniques, our team will systematically catalog the subcellular distribution of all proteins in the brain – including uncharacterized and disease-related gene products. Experimental approaches and responsibilities will involve mammalian and bacterial protein production, protein purification, and bioconjugation. The goal is to develop a panel of reagents that will enable highly multiplexed protein detection. Ideal candidates will have a background in biological sciences with the temperament to work collaboratively in a fast-paced team environment and will receive training in all relevant techniques.
At the Allen Institute, we believe that science is for everyone – and should be open to everyone. We are dedicated to combating biases and reducing barriers to STEM careers more broadly.
We also believe that science is better when it includes different perspectives and voices. We strive to make the Allen Institute a place where everyone feels like they belong and are empowered to do their best work in a supportive environment.
We are an equal-opportunity employer and strongly encourage people from all backgrounds to apply for our open positions.

REQUIRED EDUCATION AND EXPERIENCE

• Bachelor’s degree in Biology, Chemistry, Neuroscience, or related discipline

PREFERRED EDUCATION AND EXPERIENCE

• Experience with the preparation of laboratory reagents, buffers, and aliquots
• Familiarity with biochemical techniques

ADDITIONAL ELIGIBILITY QUALIFICATIONS

• All employees who work with live animals must complete an Occupational Health medical history form and/or consultation with an Occupational Health Provider and receive clearance to work with animals. Depending on your health history and job responsibilities, an annual respiratory health screening and clearance to use a respirator may also be required.

• Bacterial and mammalian cell culture
• Column-based protein purification
• Conjugation of proteins for fluorescence detection
• Follow standardized operating procedures, good laboratory practices, and regulatory requirements
• Maintain clear and accurate communication within and between teams
• Adhere to a team schedule and manage time effectively
  Note: Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. This description reflects management’s assignment of essential functions; it does not proscribe or restrict the tasks that may be assigned.