FURTHER INFORMATION

This is a Full time Fixed term role based at our Hammersmith Campus.
If you require any further details on the role please contact:
Dr Alejandra Tomas (a.tomas-catala@imperial.ac.uk)
https://www.imperial.ac.uk/people/a.tomas-catala
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities mentioned above.
We reserve the right to close the advert prior to the closing date stated should we receive a high volume of applications. It is therefore advisable that you submit your application as early as possible to avoid disappointment.
If you encounter any technical issues while applying online, please don’t hesitate to email us at support.jobs@imperial.ac.uk. We’re here to help.

ABOUT THE ROLE

We are looking for a Postdoctoral Research Associate to join our group to work on projects related to the study of the subcellular signal organisation of the glucagon receptor family (GLP-1R, GCGR, GIPR), using state-of-the-art high-throughput screening techniques, MS-based proximity localised interactomic analyses, high-resolution microscopy, and targeted biosensor approaches.

WHAT YOU WOULD BE DOING

You will join a vibrant research group where you will help elucidate the molecular mechanisms governing the subcellular organisation of signalling of the glucagon receptor family of class B1 GPCRs in pancreatic islets and other metabolically relevant cell types (hepatocytes, adipocytes, etc).

Ongoing projects in our lab include:

• Tissue selectivity of GLP-1R responses.
• Islet endocrine cell subtype-specific GLP-1R / GIPR signalling profiles.
• Glucagon receptor family missense gene variant characterisation.
• Functional validation of glucagon receptor family lipid binding sites.
• Cell type-specific glucagon receptor family protein-protein interactions.
• Control of mitochondrial and lipid droplet function by the glucagon receptor family: role of inter-organelle membrane contact sites.
• Control of GLP-1R trafficking and signalling by SUMOylation/deSUMOylation.
• Role of GIPR in the control of futile calcium cycling in adipocytes.

You will employ molecular cell biology techniques such as CRISPR/Cas9 gene editing, high-resolution/super-resolution fluorescence microscopy, high-throughput screening approaches (particularly proximity-based interactomics and library-based screening methods), click-chemistry-based assays, pharmacology methods, and cell type-specific/subcellular biosensor-based assays to characterise receptor signalling outputs from cell lines and primary cells/islets/organoids.
Please visit the following link for further information about our lab:
https://www.imperial.ac.uk/medicine/research-and-impact/groups/signalling-and-trafficking-of-receptors-in-metabolism-laboratory/