Research Associate in Host-Pathogen Interactions

at  University of Bristol

YOU SHOULD APPLY IF

You hold a PhD qualification in biochemistry, molecular biology, host-pathogen interactions, cell biology or a similar discipline, and have a proven track record for delivering research outputs, commensurate with your career stage.
Have significant expertise in protein structure-function analyses.
Have excellent verbal and written communication skills.
Are adaptable with a track record for working both independently and within a team.
Are passionate about molecular host-microbe interactions and a creative mindset to meet a challenging work program.

THE ROLE

We are seeking a post-doctoral research associate (PDRA) to work on a UKRI-funded programme dissecting the molecular mechanisms underpinning the ability of tick-borne Anaplasma phagocytophilum bacteria to subvert host cells and lead an obligate intracellular lifestyle.
This exciting project uses protein-structure function and molecular cell biology approaches to determine how effector proteins, specialised proteins which Anaplasma secretes into host cells wherein they bind cellular targets and modify host biology, enable intracellular survival of these important pathogens within host cells. Our pilot research has revealed that A. phagocytophilum effectors have wide reaching impacts on host cells, including the remodelling the host cytoskeleton and inhibition of apoptosis, and how this enables an intracellular lifestyle.
The PDRA will be based in the research group of Dr Ian Cadby and have a central role in this research programme, defining the molecular basis for host-pathogen interactions and host cell subversion alongside a technician, also to be hired.
This role is for 48 months. Please note that due to funding constraints we are extremely unlikely to offer a starting salary above £40,247 (progression above this value is possible, once appointed).

WHAT WILL YOU BE DOING?

The post holder will be responsible for the day to day organisation and execution of the programme and will work closely with other laboratory members, including a UKRI-funded research technician.

• Design and execute experiments, analyse and interpret data.
• Liaise and co-ordinate efforts with the wider collaborative team.
• Present data and research findings in various settings (group meetings, national and international conferences, etc).
• Prepare manuscripts for publication.
• Critically appraise and maintain knowledge of relevant literature.
• Support the training of other members of the team (e.g. research students) and assist in their day to day supervision.