he Associate Director, Discovery Programs, you'll work closely with our Biology, Chemistry and Translational teams.

What you'll do• In Vivo Study Design: Independently design in vivo efficacy, PK/PD, target engagement, MoA and tolerability studies in oncology models (CDX, PDX and others)• Lead CRO selection, protocol development, study oversight, troubleshooting and quality control• Analyse and integrate efficacy, PK/PD and biomarker data to guide compound optimisation and programme decisions• Manage study timelines, budgets and CRO deliverables across multiple programmes• Present results and recommendations to internal teams and external partners

What you'll bring (essential)• MSc and/or PhD in Pharmacology, Cancer Biology or a related discipline• At least 3–5 years' experience in oncology in vivo pharmacology within biotech or pharmaceutical drug discovery (industry experience is essential)• Demonstrated ability to independently design, coordinate and interpret in vivo efficacy and PKD/PD studies, including CDX and PDX models• Proven experience managing outsourced in vivo studies through CROs, from design to final data delivery• Strong understanding of PK/PD relationships, target engagement and pharmacodynamic biomarkers and their application to candidate optimisation and selection• Ability to drive multiple studies and collaborate across multidisciplinary teams

Desirable• Experience with targeted protein degraders (PROTACs, molecular glues), antibody-drug conjugates ("ADCs") or other targeted oncology therapeutics• Experience designing in vivo studies to investigate mechanism-of-action, including protein degradation, tumour drug exposure and pharmacodynamic responses• Familiarity with antibody biodistribution, payload pharmacology or translational biomarker development• Working knowledge of relevant animal welfare regulations and ethical requirements for outsourced preclinical studies

What we offerWe offer a competitive remuneration package and additional benefits, along with the opportunity to make a real impact in a growing biotech. You’ll join a supportive, collaborative team and a company that invests in your development and growth. 

How to applyPlease email your CV and a short cover note (max. 300 words) to hr@econicbio.com, with the subject line "Senior Scientist – In Vivo Pharmacology". In your cover note, describe one in vivo study you designed and managed through a CRO: the model, your role, and how the data informed a decision. Applications without this will not be considered.

This role is based in our Hammersmith office. Applicants must have the right to work in the UK.

Econic Biosciences will never ask candidates for payment or bank details during the application or interview process.