We are seeking a talented, energetic and results-oriented professional for a Research Associate role in our Kitchener lab facility.

REQUIRED SKILLS

• Master’s degree in biochemistry, Analytical Chemistry, Molecular Biology, or related fields. PhD degree in proteomics and mass spectrometry analysis is a plus.
• 0-3 years related work experience.
• Background in mass spectrometry and proteomics.
• Experience with mass spectrometry instrumentation and associated LC equipment.
• Experience in method development and optimization for targeted proteomics.
• Hands-on experience in protein sample preparation, digestion optimization, targeted enrichment for proteomics.
• Experience with DIA, SRM and PRM data analysis in Skyline is a plus.
• Experience with protein matrices software is a plus.
• Experience in protein purification (HPLC), RP, SCX, HIC, immunoprecipitation, protein cross-linking, bioanalytical HPLC, antigen/antibody purification is a plus.
• Demonstrated analytical and problem-solving abilities.
• Good knowledge of:
• Peptide or Protein LC-MS separation and data analysis.
• LC-MS method development and method optimization.
• Sample preparation in a proteomics context.
• Peptide chemistry.
• Nano and high flow rate LC-MS.
• Ability to work under the supervision of the Manager and participate in multiple projects simultaneously in a fast-paced environment.
• Meticulous attention to detail.
• Strong interpersonal skills and excellent oral and written communication skills.

• Support routine operation tasks for protein sequencing and protein characterization services. Analyze the data and generate report for customer samples.
• Develop new and improve existing procedures for sample preparation for LC-MS/MS analysis including protein characterization, target protein enrichment from serum sample and enzymatic digestion.
• Perform data analysis obtained in DDA and DIA formats and present the summary to the team.
• Review literature on protein characterization and quantitative mass spectrometry.
• Work collaboratively with other R&D members in a multi-disciplinary team setting.
• Must maintain good laboratory records.
• Must abide by all applicable standard operating procedures.
• Must abide by all applicable workplace environmental, health & safety protocols.
• Other duties as may be assigned.