Research Associate / Senior Research Associate, In Vivo Pharmacology (Contr at Septerna

South San Francisco, California, United States -

Full Time

Start Date

Immediate

Expiry Date

12 Mar, 26

Salary

45.0

Posted On

12 Dec, 25

Experience

2 year(s) or above

Remote Job

Yes

Telecommute

Yes

Sponsor Visa

Skills

In Vivo Studies, Disease Models, Data Analysis, Collaboration, Protocol Writing, Rodent Models, Sample Collection, Biomarker Discovery, Therapeutic Development, Literature Searches, Mechanism of Action, Preclinical Research, Functional PK/PD Relationships, Interdisciplinary Teamwork, Communication Skills, Detail-Oriented, Organized

Industry

Biotechnology

Description

Septerna is a biotechnology company based in South San Francisco, CA on a mission to develop life-changing medicines for patients with the vision to become the industry-leading G protein-coupled receptor (GPCR)-focused drug discovery company. The company’s Native Complex Platform™ recapitulates GPCRs with their native structure, function, and dynamics outside of the cellular context. This approach enables novel access to modern structural and screening technologies used in industrial-scale drug discovery for the entire class of GPCRs. Septerna has an emerging pipeline of GPCR-targeted small molecule programs with potential for growth to target many GPCRs that have been undruggable and unexploited to date. We are excited to expand our multidisciplinary team of individuals focused on creating revolutionary medicines to address the unmet needs of patients. At Septerna we strive to embrace diversity of thought, expertise, and background through collaboration. To join our ambitious team, be prepared to bring your real self to work every day; grow and learn from a talented team of drug hunters, scientists, and business professionals; and contribute your passion, creativity, and energy to accomplish our mission. We share a fearless pursuit of ground-breaking innovations and cultivate an environment where our employees succeed by learning from each other and working as a team. We are committed to the development of meaningful therapeutics for patients with indications of high unmet need. This is a tremendous opportunity to work with talented individuals on the frontlines of therapeutic discovery and development. You will directly help move therapies through preclinical research, positioning them for success in the clinic. The successful candidate will add their passion, unique talents, and expertise to a dynamic team motivated to discover new disease-modifying therapeutics for patients in a fast-paced environment. For more information see: www.septerna.com. THE ROLE: This is a contracted position requiring 40 hours per week for a 12-month term. The Research Associate / Senior Research Associate will primarily be responsible for the development and conduct of in vivo, ex vivo, as well as in vitro studies in Disease Biology and Translational Sciences to support the advancement of Septerna’s small molecule drug discovery pipeline. They will work independently and collaboratively in an inter-disciplinary setting to design and execute experiments in preclinical models to understand in vivo pharmacology, establish PK/PD relationships, and inform the efficacy of Septerna’s therapeutic candidates. They will help generate and analyze functional in vitro, in vivo, and ex vivo data to determine the therapeutic mechanism of action, and rank candidates for preclinical development. They may also engage in biomarker discovery efforts by utilizing a variety of in vitro, in vivo and ex vivo models to enable and inform effective therapeutic development. This role is expected to be primarily in the lab with some desk work. We are committed to the development of meaningful therapeutics for patients with indications of high unmet need. This is a tremendous opportunity to work with talented individuals on the frontlines of therapeutic discovery and development. You will help move therapies through preclinical development, positioning them for success in the clinic. The successful candidate will add their passion, unique talents, and expertise to a dynamic team on the frontlines of innovative therapeutic development. The position is based in South San Francisco, CA. *Title commensurate with experience Key Responsibilities include but are not limited to: Design and execute in vivo pharmacology studies to understand therapeutic mechanism in relevant disease models Generate, analyze, document, and help interpret data to establish functional PK/PD relationships Work collaboratively to determine the mechanism of action of drug candidates in in vivo, in vitro and ex vivo models Be a member of multiple project teams and present results in lab, team and department meetings Perform in literature searches, read and interpret papers to help design and trouble-shoot in vivo and in vitro experiments Help in authoring in vivo pharmacology study designs, protocols, and reports to support regulatory filings Follow all company policies/practices, and maintain accurate records and notebooks REQUIRED EDUCATION, SKILLS & EXPERIENCE BSc or MSc in Pharmacology, Toxicology, or related biological science 2- 4 years of direct full-time hands-on experience with in vivo studies or disease models in academia or the biotechnology and pharmaceutical industries Demonstrated ability to be hands on and work directly with rodent models (mice and rats), including multiple routes of administration (e.g. oral, subcutaneous, intraperitoneal, intravenous, intramuscular) and sample collection (e.g. submandibular bleed, tail vein bleed, cardiac puncture, etc). Experience working with other scientists to analyze, interpret, and present data Ability to collaborate in writing protocols and trouble-shooting biological experiments Detail-oriented and organized, with strong interpersonal skills for clear and effective communication – ability to proactively engage and collaboration with colleagues PREFERRED SKILLS & EXPERIENCE Experience working with protein and RNA/DNA (e.g. ELISA, qPCR) Experience working with primary cells or ex vivo models or in vivo species Experience measuring and interpreting rodent behavior Experience working with generation of surgical models in rodents Previous work on therapeutic discovery and development programs in the field of endocrine, inflammatory, neuroscience or metabolic diseases Experience working with vendors and CROs to execute studies, analyze data, and generate reports The anticipated salary range for candidates who will work in South San Francisco, CA is $37.00/hr - $45.00/hr. Individual pay may vary based on additional factors, including, and without limitation, job-related skills, experience, work location and relevant education or training. Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited. We are an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status. Septerna participates in the E-Verify program. California Consumer Privacy Act Privacy Notice For Job Applicants. If you are a California resident, click here for our CCPA Notice.

Responsibilities

The Research Associate / Senior Research Associate will design and execute in vivo pharmacology studies to understand therapeutic mechanisms in relevant disease models. They will generate and analyze data to establish functional PK/PD relationships and support the advancement of Septerna’s drug discovery pipeline.