Parallel Squared Technology Institute (PTI) is a non-profit research institute aiming to catalyze a leap in protein analysis technology and use it to explore new biological frontiers. PTI supports open research and educational opportunities supporting rapid career development for scientists, engineers, and mathematicians.
Why? Protein dysfunctions directly cause many diseases, such as Alzheimer’s disease. Yet, proteins remain understudied because of technological hurdles.
How? To resolve these limitations, PTI will develop mass tags enabling a new framework for multiplexed protein analysis by mass spectrometry towards achieving 100-fold increase in throughput. Scientists at and collaborating with the institute will use these gains to directly investigate disease mechanisms and resolve problems that have proven intractable for decades. Our proof of principle technology and strategies are outlined at: parallelsq.org.

SUMMARY OF POSITION

We are looking for an individual contributor with previous experience in optimizing small molecule/peptide labeling chemistries. This person will lead the design of new labeling methods for mass tag development. This position will involve working with single cell ’omics pipelines, integrating optimizations for LC-MS systems and downstream analysis. The successful candidate will work in a highly interdisciplinary team environment with other scientists. In order to be seriously considered for this position, we require a cover letter as part of the candidate’s application.

QUALIFICATIONS:

• 5+ years of experience in medicinal chemistry in a professional setting OR PhD in Chemistry or Chemical Biology or related field
• Experience in optimizing organic chemistry reaction conditions
• Strong quantitative and analytical skills, with a proclivity for reasoning from first principles
• Highly motivated and organized researcher with strong analytical skills

PREFERRED QUALIFICATIONS:

• Experience with mass spectrometry (LC-MS) analysis of small molecules, peptides or proteins
• Experience in synthesizing small molecules for protein modification
• Strong foundation in diverse synthetic transformations and reaction strategies

• Discover and optimize new labeling chemistries for covalent modification of proteins and peptides
• Develop and optimize sample clean-up approaches
• Define new directions for technology development that can unlock new testable hypotheses
• Mentor scientists and research associates
• Prepare internal reports and manuscripts as well as present results at internal or external scientific meetings as appropriate
• Demonstrate a commitment to diversity, inclusion, and cultural awareness through actions, interactions, and communications with others
• Other duties as assigned