Start Date
Immediate
Expiry Date
24 Jul, 25
Salary
0.0
Posted On
17 Jun, 25
Experience
3 year(s) or above
Remote Job
Yes
Telecommute
Yes
Sponsor Visa
No
Skills
Good communication skills
Industry
Hospital/Health Care
ABOUT US
The UCL Division of Psychiatry, located within the Faculty of Brain Sciences, is a world-renowned centre of excellence in mental health research. Our mission is to improve mental health through cutting-edge research and education. By leveraging insights from basic science, we address clinical problems with the aim of improving patient outcomes and public health. Moreover, we take pride in delivering innovative teaching that is directly relevant to clinical practice and informed by our research. Join our team and help us drive forward the field of mental health research and education.
The DVC-RISK study aims to understand the genetic and environmental causal determinants of vascular dementia. DVC-RISK entails five key objectives to which the postholder would contribute:
1) Develop a ‘Brain Genetics Platform’, bringing together data from donated brain tissue samples, that have linked genotype data, from across the globe.
2) Conduct the first ever genome-wide association study (GWAS) of dementia with a vascular component, using neuropathological diagnoses from post-mortem brain tissue samples.
3) Develop genetic and phenotypic prediction models to help identify susceptible individuals in a clinical setting.
4) Discover how genetic risk for vascular dementia affects cognitive function across the life course.
5) Identify modifiable causal risk factors for vascular dementia
ABOUT THE ROLE
The postholder will be required to manage and securely store large quantitative datasets, and will conduct quality control checks on newly received genotype data from post-mortem brain tissue samples. They will be required to conduct advanced genetic epidemiological analyses such as multivariable GWAS and genomic structural equation modelling, polygenic risk score an analysis and Mendelian randomization, and write up study findings for scientific publications. The postholder will have the opportunity to present key research findings at international conferences, and help develop research objectives and contribute to preparing proposals to external funding bodies. The postholder must be able to work collaboratively, help supervise the work of others and act as team leader as required.
The post is initially funded until 31st July 2026 at 100% full-time equivalent. However, please note that this post is part of a longer-term funded project and it is very likely that the post will be extended for up to a further three years.
As well as the exciting opportunities this role presents, we also offer some great benefits some of which are below:
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