ABOUT US

Our mission is to maximise and advocate for the holistic health of all children, young people and the adults they will become, through world-class research, education and public engagement. The UCL GOS ICH, together with its clinical partner Great Ormond Street Hospital for Children, forms the largest concentration of children’s health research outside North America. The 2024-29 GOS ICH strategy focuses on its five scientific programmes. GOS ICH’s activities include active engagement with children and families, to ensure that our work is relevant and appropriate to their needs. GOS ICH generates the funding for our research by setting out our proposals in high quality applications to public, charitable and industrial funding bodies and disseminates the results of our research by publication in the medical and scientific literature, to clinicians, policy makers and the wider public. The Institute offers world-class education and training across a wide range of teaching and life learning programmes which address the needs of students and professional groups who are interested in and undertaking work relevant to child health. GOS ICH holds an Athena SWAN Charter Gold Award. Please only attach relevant documents to your application (qualifications, cover letters, supporting statements) and avoid attaching large files e.g. research papers, thesis, publications etc.

An opportunity has become available to join a research group at the UCL Great Ormond Street Institute of Child Health in a research project to develop drug switchable chimeric antigen receptors targeting childhood solid cancers. The appointee will join the group to complete the last approximately 15 months of a 3 year project and so previous experience in CAR-T cell molecular cloning and functional assays including in vivo assays is essential. The appointee will be integrated into the preclinical team run by Professor John Anderson in the Zayed Centre at the Institute of Child Health focused on development of CAR-T therapeutics for paediatric cancers. There will be close working with collaboration partners. Flexibility in working hours will be required to accommodate weekend or out of hours tasks if required. The Zayed Centre for research in rare disease in childhood is a new research facility in the UCL Institute of Child Health. Five Principal Investigators share research space. The appointment is for 9 months. The appointee will fall under the overall line management of Professor John Anderson. Main purpose summarised as follows: • Generating variants of chimeric receptors for transduction into human T cells using molecular cloning techniques. • Performing Functional immune assays of CAR-T candidates evaluated by multiparametric flow cytometry • Evaluation of new CAR-T products in multi-arm animal therapeutics trials in tumour bearing mice. • Working under line management of Prof Anderson and with day-to-day monitoring and supervision by members of the research laboratory team. • Working within a team of scientists with focus on development of new therapies for childhood cancer • Writing up of results for scientific publication Duties and responsibilities: • Ensuring data integrity and excellent record keeping • Performing experimental assays for designated projects as directed by the PI • Organising and leading and executing multi-arm in vivo studies using experimental mice • Ensuring compliance with GCLP and the HTA The salary offered in this post is £45,103 per annum and is funded for approximately 9 months in the first instance.