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UCL is one of the top Universities in the world with superb facilities for biomedical sciences and its translation to human disease. The successful candidate will focus on translational research in autoimmune rheumatic disease spanning disease pathomechanisms toward translational medicine to early phase clinical trials. Thus, contributing to the development of precision medicine and novel therapies. The work will build on existing excellent links with UCLH and complete a project that commenced early in 2025. The work will involving patient recruitment, processing of samples from patients with autoimmune disease and carried out at the Centre for Rheumatology in the Rayne Building, which has outstanding flow-cytometry infrastructure and technical support.

This six-month research position starting September 2025 focuses on systemic lupus erythematosus (SLE) immunology research. The role investigates B cell and T cell dysfunction in SLE patients to identify biomarkers predicting response to B cell targeted therapies. The researcher will independently conduct hands-on laboratory work using advanced molecular and cellular techniques, including multiparameter spectral flow cytometry, ELISA, and cytometric bead arrays. Key responsibilities include processing patient samples, performing whole blood depletion assays, and analysing T cell activation patterns to evaluate novel B cell targeting agents. Beyond laboratory work, the position requires meticulous documentation, sample management, and maintaining regulatory compliance. The researcher will contribute to manuscript preparation, grant writing, and present findings to colleagues. Laboratory management duties include inventory control and safety protocol adherence. This translational research directly impacts clinical treatment outcomes for SLE patients. The role offers professional development opportunities through industry and academic collaborations, making it ideal for immunology researchers seeking meaningful clinical research experience. This post is available for 6 months.