ABOUT US

The Ribosome Laboratory, headed by Dr. Lisa Cabrita and Prof. John Christodoulou is a highly dynamic research environment that integrates molecular and cell biology with structural and computational biology to address key questions in how proteins first begin to form their structures on ribosomes, and how this process can go wrong and lead to disease.
The laboratory is part of the Biosciences Division, a centre of research excellence and one of the largest Divisions within UCL. Research activities in the Division and the linked Institute of Structural and Molecular Biology are underpinned by state-of the-art research facilities hosting and developing methodologies, including cryo-electron microscopy, NMR spectroscopy, X-ray crystallography, single molecules methods, ion mobility mass spectrometry laboratories, cell biology, optical microscopy and bioinformatics.
The Biosciences Division coordinates a range of undergraduate and master’s programmes and hosts a large number of postgraduate research students funded by MRC, BBSRC, EPSRC and many others. Symposia, retreats and seminar series are an important part of the experience of our community.
The Cabrita lab promotes independent and creative thinking, and projects often span research disciplines, with a strong interest in defining mechanism and structure in high definition. This project is an exciting opportunity to explore a new area of co-translational protein mis-assembly in conformational diseases

ABOUT THE ROLE

This is a multi-disciplinary role investigates a molecular basis of co-translational misfolding and mis-assembly, with questions ranging from the role of the ribosome in early protein misfolding events, the cell’s response, through to understanding how aberrant structures are formed in cells.

The project will involve studying protein translation and ribosomal complexes using molecular cell biology and biophysical approaches (in vitro and cell-based), with a view to expanding to cryoEM to study ribosomal complexes at high-resolution, in collaboration with the Christodoulou group. The post hold will be an active member of the Cabrita/Christodoulou laboratories and interface with collaborators.

• This is a fixed-term role for 24 months from the time of appointment, in the first instance.
• Research Fellows - ‘Appointment at Grade 7 is dependent upon having been awarded a PhD; if this is not the case, initial appointment will be at Grade 6B (salary £38,607- £41,255 per annum) per annum) with payment at Grade 7 being backdated to the date of final submission of the PhD Thesis.’
• This appointment is subject to UCL Terms and Conditions of Service for Research and Professional Services Staff. Please visit https://www.ucl.ac.uk/human-resources/conditions-service-research-teaching-and-professional-services-staff for more information.
• This appointment is subject to UCL Terms and Conditions of Service for Academic Staff. Please visit https://www.ucl.ac.uk/human-resources/policies/2021/jun/conditions-service-academic-stafffor more information.

A job description and person specification can be accessed at the bottom of this page.
If you have any queries about the role, please contact Lisa Cabrita at l.cabrita@ucl.ac.uk

As well as the exciting opportunities this role presents, we also offer some great benefits some of which are below:

• 41 Days holiday (27 days annual leave 8 bank holiday and 6 closure days)
• Additional 5 days’ annual leave purchase scheme
• Defined benefit career average revalued earnings pension scheme (CARE)
• Cycle to work scheme and season ticket loan
• Immigration loan and expenses
• Relocation scheme for certain posts
• On-Site nursery
• On-site gym
• Enhanced maternity, paternity and adoption pay
• Employee assistance programme: Staff Support Service
• Discounted medical insuranc