RESEARCH OFFICER / SENIOR RESEARCH OFFICER- TUMOUR ORGANOID RESEARCH (STCC)

Overview

The Consortium for Clinical Research and Innovation, Singapore (CRIS) brings together six national R&D, clinical translation and service programmes to advance clinical research and innovation for Singapore and establish important capabilities for a future-ready healthcare system. The Business Entities under CRIS include:

• Singapore Clinical Research Institute (SCRI)
• National Health Innovation Centre (NHIC)
• Advanced Cell Therapy and Research Institute, Singapore (ACTRIS)
• Precision Health Research, Singapore (PRECISE)
• Singapore Translational Cancer Consortium (STCC)
• Cardiovascular Disease National Collaborative Enterprise (CADENCE)

Together, CRIS makes a positive difference to Singapore patients and researchers by ensuring that these clinical research platforms and programmes are at the cutting edge of capability development and innovation. If you are as passionate as we are in clinical trials and research, we want you!

QUALIFICATIONS

• Bachelor’s Degree in Cancer Biology, Molecular Biology, Immunology, or other strongly related scientific discipline.
• Prior experience with cell culture, 3D cell culture, organoid models and molecular biology techniques is highly desirable.
• Preferably with 2-5 years’ experience in a clinical or research laboratory setting.
• Experience in Next-Generation Sequencing
• Able to learn new techniques, perform multiple tasks simultaneously and deliver quality work under tight timelines.
• Meticulous with an attention to details.
• Team player, good interpersonal, communication and presentation skills.
• Proficient in Microsoft Office, e.g. PowerPoint, Word and Excel.
  What you need to know
  Successful candidate will be offered a 3-year renewable contract. We regret that only shortlisted candidates will be contacted.

For more information about CRIS and the Business Entities, visit our websites below:

• CRIS – https://www.cris.sg
• SCRI – https://www.scri.edu.sg
• NHIC – https://www.nhic.sg
• ACTRIS – https://www.actris.sg
• PRECISE – https://www.npm.sg
• STCC – https://www.stcc.sg
• CADENCE – https://www.cris.sg/our-programmes/cadence/

We are seeking a highly motivated Research Officer or Senior Research Officer to join our organoid research team. The successful candidate will contribute to national-level projects by projects by establishing and maintaining patient-derived organoid (PDO) models and catalogue. This is a collaborative position involving coordination across research institutions in Singapore.

• Perform patient-derived organoid (PDO) culture, co-ordinate with multiple organoid research groups for collection and propagation of organoids for national level projects.
• Optimize protocols for tumour organoid culture and expansion.
• Establish and implement standardized workflows for organoid collection, organoid culture, expansion, molecular characterization and clinical annotations for collaborative studies.
• Conduct cellular and molecular assays such as RNA/DNA extraction, qPCR, Immunofluorescence, H&E staining, High-throughput compound screening, Cytotoxicity assays, Next-Generation Sequencing (NGS) etc.
• Organize and co-ordinate meetings with organoid research groups and industry partners.
• Compile and curate a national list of available tumour organoid models with associated annotations, protocols, and SOPs from collaborators.
• Support the development of STCC national tumour organoid catalogue.
• Capable of working in a team to survey scientific literatures, optimize standard protocols, execute and troubleshoot as seen appropriate.
• Review scientific literature, troubleshoot protocols, and contribute to protocol optimization.
• Maintain high standards of research integrity, including meticulous documentation and execution.
• Demonstrate strong initiative, willingness to learn, and the ability to work effectively within a multidisciplinary team.
• Participate in and present research findings at group meetings and conferences.
• Prepare technical reports, risk assessments, and SOPs.
• Adhere to laboratory safety procedures and perform other duties as required.