Research Postdoctoral Fellow - Cancer Immunotherapy at Children’s Hospital of Philadelphia

Philadelphia, Pennsylvania, United States -

Full Time

Start Date

Immediate

Expiry Date

22 Dec, 25

Salary

110400.0

Posted On

23 Sep, 25

Experience

0 year(s) or above

Remote Job

Yes

Telecommute

Yes

Sponsor Visa

Skills

Cancer Biology, Genomics, Immuno-Oncology, Research Methodologies, Data Evaluation, Lab Management, Grant Writing, Project Planning, Technical Skills, Supervision, Clinical Trials, Therapeutic Resistance, Mouse Models, Immunotherapeutic Strategies, Next-Generation CAR T Cell Therapy, Antibody-Drug Conjugate Development, Correlative Biology Studies

Industry

research

Description

SHIFT: Day (United States of America) Seeking Breakthrough Makers Children’s Hospital of Philadelphia (CHOP) offers countless ways to change lives. Our diverse community of more than 20,000 Breakthrough Makers will inspire you to pursue passions, develop expertise, and drive innovation. At CHOP, your experience is valued; your voice is heard; and your contributions make a difference for patients and families. Join us as we build on our promise to advance pediatric care—and your career. CHOP does not discriminate on the basis of race, color, sex, national origin, religion, or any other legally protected categories in any employment, training, or vendor decisions or programs. CHOP recognizes the critical importance of a workforce rich in varied backgrounds and experiences and engages in ongoing efforts to achieve that through equally varied and non-discriminatory means. A Brief Overview Under the direction/guidance of a mentor (principal investigator), assumes responsibility for a specific, on-going research project. The experience will serve to extend, refine and enhance skills necessary for professional and career development, and will enable the individual to broaden his/her scientific background by acquiring new research capabilities. It is expected that this individual will conduct independent scholarly research, and will contribute directly to the overall research goals of the project and the research group. This role will be expected to participate in project planning, recording and interpretation/evaluation of data, and communication of results. This position will also be expected to acquire technical, lab management, and manuscript/grant writing skills; and participate in seminars, lectures, poster sessions and presentations at national meetings. This role also may be required to supervise junior lab members, develop new methods and protocols for research, and assist with the development of other research projects in the lab. About the Laboratory The postdoctoral fellow (postdoc) will conduct translational pediatric cancer biology, genomics, and immuno-oncology research under the direction/guidance of Dr. Kris Bosse at the Children’s Hospital of Philadelphia (CHOP) and the University of Pennsylvania (UPenn). Dr. Bosse’s laboratory is focused on understanding the underlying molecular mechanisms driving neuroblastoma tumorigenesis and developing new therapies, including immunotherapeutic strategies, for this and other aggressive pediatric cancers (see Bosse et al., Cancer Cell, 2017; Raman et al., Cell Reports Medicine, 2021; Heitzeneder et al., Cancer Cell, 2022; Pascual-Pasto et al, JITC, 2022, Foster et al, JITC, 2022, Pascual-Pasto et al, Nature Communications, 2024 and Pascual-Pasto et al, Clinical Cancer Research, 2024 as examples). The postdoc will join a growing translational research team based in his laboratory. Several opportunities exist to work in collaboration with several other laboratories at CHOP/UPenn and at 10 other institutions as part of the St. Baldricks-Stand Up To Cancer Immunogenomics Team in developing and validating new immunotherapeutic strategies for pediatric cancers. Multiple specific projects exist under this umbrella designed to discover and develop novel, impactful new immune-based therapies for children with cancer. Available projects include (but are not limited to) translating current immunotherapies in the lab across pediatric cancers, new immunotherapeutic target discovery in neuroblastoma and other pediatric cancers, next-generation chimeric antigen receptor (CAR) T cell therapy and antibody-drug conjugate (ADC) development, defining mechanisms of tumor cell intrinsic and extrinsic immune escape, deciphering the key biologic functions of prioritized immunotherapeutic targets, dual antigen immunotherapeutic targeting, CAR vaccination approaches, and correlative biology studies from ongoing clinical trials that developed from work done in the Bosse laboratory. The Bosse laboratory is also interested in utilizing syngeneic neuroblastoma models to define critical synergistic CAR T cell and ADC therapeutic combinations that can be translated to the clinic. Other opportunities are available in the laboratory to explore and define the underlying mechanisms of therapeutic resistance and disease progression in neuroblastoma utilizing data acquired from the serial profiling of circulating tumor DNA (ctDNA) in this disease (see Bosse et al., Cancer Discovery, 2022 as an example). Key putative genomic mechanisms of therapeutic resistance have been identified that are primed for functional validation studies. Cancer and molecular biology experience are required, and familiarity with advanced genomic and immuno-oncology techniques and methods, as well as experience with in vivo mouse models, are preferred skills. This job is open to those seeking first or second post-docs. What you will do Conduct independent scholarly research and develop new methods and protocols Participate in project planning, recording and evaluation of data Acquire technical, lab management and grant writing skills Participate in seminars, lectures, poster sessions and presentation at national meetings Supervise junior lab members Assist with other research projects Education Qualifications Doctorate - Required Skills and Abilities Ability to wear a respirator device To carry out its mission, CHOP is committed to supporting the health of our patients, families, workforce, and global community. As a condition of employment, CHOP employees who work in patient care buildings or who have patient facing responsibilities must receive an annual influenza vaccine. Learn more. EEO / VEVRAA Federal Contractor | Tobacco Statement SALARY RANGE: $20,800.00 - $110,400.00 Annually Salary ranges are shown for full-time jobs. If you're working part-time, your pay will be adjusted accordingly. If you are applying for a Research Post-Doctoral Fellow role, please refer to this link for salary guidelines (copy & paste into your browser): https://www.research.chop.edu/services/hiring-a-postdoctoral-fellow#collapse-accordion-3523-3 ------------------- At CHOP, we are committed to fair and transparent pay practices. Factors such as skills and experience could result in an offer above the salary range noted in this job posting. Click here for more information regarding CHOP's Compensation and Benefits.

Responsibilities

The postdoctoral fellow will conduct independent scholarly research and develop new methods and protocols. They will also participate in project planning, data evaluation, and assist with other research projects.