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ABOUT THE ROLE

We are seeking an ambitious and creative Research Technician to join the group of Prof Ed Tate at Imperial College to support our teams working on antibody-drug conjugates (ADCs) and small molecule drug discovery through high-throughput intact protein mass spectrometry.
Bioconjugation of payloads to antibodies and other biological delivery vehicles offers a unique mechanism for the targeted delivery of cytotoxic molecules selectively to diseased tissue, vastly expanding the variety of payloads which can be used in the treatments of disease. In the Tate group we work on all aspects of bioconjugate development with projects spanning payload diversification, discovery and delivery vehicle optimisation/expansion. This is a rapidly evolving field, and ADC-related spinouts from our lab have raised over $100 million in Venture investment to date (e.g. Myricx Bio, https://myricxbio.com/). We also undertake targeted covalent drug discovery, using high-throughput intact protein LC-MS as a key screening assay platform.

WHAT YOU WOULD BE DOING

Your role will be to support a diverse project portfolio through design and execution of bioconjugation experiments from initial conjugation, through reaction monitoring and analysis and purification of synthesised conjugates. This role will have a focus on the use of intact protein Mass Spectrometry (MS) at our state-of-the-art Agilent Measurement Suite (https://www.imperial.ac.uk/chemistry/research/facilities/agilent-measurement-suite/) and you would also support projects using high-throughput MS screening to identify compounds which can covalently label proteins, using state of the art equipment including the Agilent RapidFire platform.
You will be an enthusiastic and capable individual with prior relevant experience gained within industry or an academic environment. You will support the Tate group working across a variety of chemical biology and drug discovery projects, with a specific focus on bioconjugations and protein mass spectrometry. You may also be involved in collaborations with biopharma companies in the ADC and covalent ligand discovery space, for example our spinout company Siftr Bio (https://www.linkedin.com/company/siftr-bio/).

Essential criteria for the role include:

• A minimum of a BSc qualification in in chemistry, chemical biology, biochemistry, or a closely related field, or an equivalent level of professional qualifications and experience.
• Experience in running bioconjugations and the use of related analytical Mass Spectrometry methods

Working within the Tate group will give you the opportunity to work with over 60 scientists at all levels from masters to postdoctoral researchers with our state-of-the-art labs in West London. You will be joining a team with an excellent track record in the areas of bioconjugation and covalent drug design innovation (https://pubs.acs.org/doi/10.1021/acschembio.0c00285, https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c02123).

• The opportunity to continue your career at a world-leading institution and be part of our mission to continue science for humanity.
• Grow your career: Gain access to Imperial’s sector-leading dedicated career support for researchers as well as opportunities for promotion and progression
• Sector-leading salary and remuneration package (including 39 days off a year and generous pension schemes)