A 3-year research technician post is available on a Wellcome Trust-funded project investigating how menopause may increase Alzheimer’s disease (AD) risk in females. The project will investigate whether menopause increases Alzheimer’s disease (AD) risk in females by exacerbating vascular dysfunction. There is potential to extend the post beyond the initial 3 years.
The position is supervised by Dr Kira Shaw and Dr Ingo Schiessl and is part of the wider Brain Inflammation Group (braininflamelab.org). The successful candidate will also work closely with other group members, including Professor Stuart Allan, and with collaborators in the Microvascular@Manchester group (microvascularmanchester.com), including Dr Harry Pritchard and Professor Adam Greenstein. The post is based within the Division of Neuroscience at the University of Manchester.
We are seeking a candidate with a background in neuroscience or a related discipline, ideally with experience in in vivo or molecular techniques. You will work on projects investigating the neurovascular mechanisms at the onset of menopause and/or Alzheimer’s disease (https://wellcome.org/research-funding/funding-portfolio/funded-grants/does-menopause-enhance-alzheimers-disease-risk).

• Breeding and maintaining transgenic mouse colonies
• Performing surgeries to support in vivo imaging (e.g. multi-photon microscopy, optical imaging spectroscopy)
• Conducting behavioural testing for cognitive function
• Post-mortem analysis (e.g. immunohistochemistry, RNA sequencing) to identify candidate treatments targeting menopause-sensitive vasodilation pathways.
  Full training will be provided for any unfamiliar techniques. As a Wellcome Trust-funded researcher, you will have access to 10 training days per year. This role offers the chance to contribute to a well-supported research programme while gaining broad technical experience and developing your career in experimental neuroscience. The successful candidate will also have opportunities to collaborate across the wider lab and research networks.