Safety Evidence Synthesis Manager at AstraZeneca

Mississauga, Ontario, Canada -

Full Time

Start Date

Immediate

Expiry Date

23 Jan, 26

Salary

0.0

Posted On

25 Oct, 25

Experience

5 year(s) or above

Remote Job

Yes

Telecommute

Yes

Sponsor Visa

Skills

Epidemiology, Public Health, Evidence Synthesis, Systematic Reviews, Critical Appraisal, Data Extraction, Pharmacovigilance, Risk Management, Drug Safety, Medical Terminology, Collaboration, Literature Reviews, Adverse Event Reporting, Quality Assessment, Search Strategies, Meta Analysis

Industry

Pharmaceutical Manufacturing

Description

At AstraZeneca, we pride ourselves on crafting a collaborative culture that champions knowledge-sharing, ambitious thinking and innovation – ultimately providing employees with the opportunity to work across teams, functions and even the globe. Recognizing the importance of individualized flexibility, our ways of working allow employees to balance personal and work commitments while ensuring we continue to create a strong culture of collaboration and teamwork by engaging face-to-face in our offices 3 days a week. Our head office and BlueSky Hub in downtown Toronto are purposely designed with collaboration in mind, providing space where teams can come together to strategize, brainstorm and connect on key projects. Our dedication to sustainability is also central to our culture and part of what makes AstraZeneca a great place to work. We know the health of people, the planet and our business are interconnected which is why we’re taking ambitious action to tackle some of the biggest challenges of our time, from climate change to access to healthcare and disease prevention. Introduction to role: Are you ready to lead the charge in transforming patient safety through evidence synthesis? AstraZeneca is seeking a dynamic Safety Evidence Synthesis Manager to join our Safety Epidemiology team. In this pivotal role, you will be responsible for conducting targeted and systematic literature reviews, critical appraisals, and AI-assisted evidence synthesis. You will also play a key role in establishing best practices across the organization. Your work will drive scientific and operational execution of evidence synthesis and literature reviews that support post-marketing commitments and contextualization projects. Collaborate with Global Patient Safety, Global Regulatory, Global and Local Medical teams, and R&D to shape strategy, align objectives, and deliver high-quality, decision-ready outputs. Accountabilities Author and govern protocols: design and write protocols for rapid, scoping, and systematic reviews, as well as meta analyses, ensuring methodological robustness and alignment with regulatory expectations. Execute and oversee reviews: lead development of search strategies; supervise and perform study screening, data extraction, evidence synthesis, quality/risk of bias assessment, and report writing for patient safety–focused questions. Deliver ad hoc reviews and appraisals: conduct targeted literature assessments and critical appraisals of published safety studies related to medicinal products and devices; communicate findings with clear implications for pharmacovigilance and risk management. Essential Skills/Experience PhD (or equivalent) in epidemiology, public health, or related health science with substantial evidence synthesis experience; or MSc/MPH with extensive expertise in systematic reviews. Hands-on experience planning, conducting, and delivering systematic and ad hoc literature reviews end to end. Advanced skill in critical appraisal of study designs and published literature using established appraisal tools and reporting guidelines. Experience synthesizing, interpreting, and communicating published literature and medical information on drug and patient safety, including adverse event reporting. Desirable Skills/Experience Strong commitment to advancing the quality and impact of literature reviews and evidence synthesis in drug safety. Broad knowledge of patient safety, drug safety, epidemiology, and medical terminology. Experience collaborating with internal and external experts, collaborative groups, and contract research organizations (CROs). Great People want to Work with us! Find out why: GTAA Top Employer Award for 11 years Top 100 Employers Award Canada’s Most Admired Corporate Culture Learn more about working with us in Canada View our YouTube channel Are you interested in working at AZ, apply today! AstraZeneca is an equal opportunity employer that is committed to diversity and inclusion and providing a workplace that is free from discrimination. AstraZeneca is committed to accommodating persons with disabilities. Such accommodation is available on request in respect of all aspects of the recruitment, assessment and selection process and may be requested by emailing AZCHumanResources@astrazeneca.com. #LI-Hybrid Date Posted 24-Oct-2025 Closing Date 30-Oct-2025 AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

Responsibilities

The Safety Evidence Synthesis Manager will lead the charge in transforming patient safety through evidence synthesis, conducting targeted and systematic literature reviews. This role involves collaborating with various teams to shape strategy and deliver high-quality outputs that support post-marketing commitments.