JOB DESCRIPTION

Vertex is seeking a talented scientist to join the Analytical Development organization in Boston, MA. This individual will help advance transformative medicines by performing analytical chemistry activities through all stages of clinical development. This role is in the Liquid Chromatography Subject Matter Expert (SME) team, dedicated to small molecule and synthetic peptide/oligonucleotide LC method development for both drug substances and drug products. The successful candidate will lead LC method development activities for assigned projects, participate as a core member in cross-departmental program teams, and serve as a technical expert in the space of liquid chromatography.
This is an onsite position.

KNOWLEDGE AND SKILLS:

• Design and execution of complex, challenging experiments
• Technical expertise in analytical techniques that include HPLC, UHPLC, IC, or LC-MS
• Demonstrated written and verbal communication skills especially in peer-directed presentations and report writing
• Experience in HPLC/UHPLC method development
• Advanced troubleshooting skills and problem-solving capabilities
• Strong analytical data assessment, review, and interpretation skills
• Ability to work in a fast-paced environment, managing priorities, and maintaining timelines

EDUCATION AND EXPERIENCE:

• Ph.D. (or equivalent degree) and 0-3 years of relevant post-doctoral employment experience in analytical chemistry or the life/physical sciences
• Masters Degree (or equivalent degree) and 3+ years of relevant employment experience, or
• Bachelors Degree (or equivalent degree) and 6+ years of relevant employment experience

• Develop analytical methods on HPLC/UHPLC with various detection systems (UV, QDa, CAD, etc.) for small molecules and synthetic peptides/oligonucleotides
• Conduct experiments independently following established methodology, procedures, and SOPs
• Exercise solid judgment to prioritize studies while considering feasibility, timelines, and project impact
• Independently prepare presentations and presents experimental conclusions at internal or external meetings
• Work collaboratively, cross-functionally, and within the team to achieve program goals
• Author and review method documents, analytical study protocols, and reports
• Maintain accurate notebook entries and adhere to governing SOPs
• Perform data verification/review of peer notebooks