Scientist at Arcellx

Rockville, Maryland, United States -

Full Time

Start Date

Immediate

Expiry Date

26 Apr, 26

Salary

125000.0

Posted On

26 Jan, 26

Experience

2 year(s) or above

Remote Job

Yes

Telecommute

Yes

Sponsor Visa

Skills

Cell Biology, Tumor Biology, Cancer Modelling, CAR-T Cell Biology, Flow Cytometry, Immune Cells, Cytotoxicity Assays, Proliferation Assays, Cytokine Measurement, Lentivirus Generation, Molecular Biology Techniques, In Vivo Models, Data Analysis, Experimental Methods, Communication Skills, Collaboration

Industry

Biotechnology Research

Description

Who We Are Arcellx is a public, clinical-stage biotechnology company reimagining cell therapy by engineering innovative immunotherapies for patients with cancer and other incurable diseases. We believe that cell therapies are one of the forward pillars of medicine and our mission is to destroy cancer and advance humanity by developing cell therapies that are safer, more effective, and more broadly accessible. Our team members are made up of talented innovators and dreamers working from our offices in Rockville, Maryland, and Redwood City, California. At Arcellx, we hire exceptional people and create a fun, diverse, supportive, and informal environment that allows everyone to do their best work. What Matters to Us Living our core values is essential to maintaining a work environment that is high-performing, inclusive, and collaborative. We look for candidates who demonstrate strong values alignment and bring different backgrounds, viewpoints, and abilities to the team. Arcellx Core Values Start with authenticity: We foster an inclusive environment where each person can bring their authentic self to work. Think ‘we’ before ‘me’: We prioritize collective success, collaborating and supporting one another to achieve our shared goals. Embrace the challenge: We deliver exceptional results by working with shared determination and a commitment to doing what’s right. How You’ll Make a Difference As a Scientist within our Cell Biology group, you will have a direct impact our drug pipeline as a lab-based contributor and functional area lead within the project setting. Our potentially life-saving treatments would not exist without the work of our talented scientists. Your work as a member of our experienced cross-functional team will drive discovery, characterization, and optimization of novel cell-based therapies. The “Fine Print” – What You’ll Do Contribute to one or more pipeline programs, working collaboratively with cross-functional teams to ensure the timely generation and dissemination of critical program data to enable data-driven decisions. Design and execute experiments independently with minimal supervision, as well as effectively plan and organize work activities and prioritize task completion. Serve as a functional area lead within a project setting; helping to derive timelines, plan, and execute to help achieve project goals. Stay up to date with relevant technical and intellectual scientific expertise in tumor biology and cancer modelling, particularly as it relates to CAR-T cell biology or other cell-based therapies. Skills and Experience We Look For Candidates with a master’s degree and 4-6+ years research experience within the pharmaceutical industry or a PhD-level scientist from a relevant field and 0-2 years industry experience. Specific backgrounds of interest are: Chimeric Antigen Receptor (CAR) T-cells or alternative cell-based cancer therapeutics Other Immuno-modulatory drug modalities (T-cell engagers or multi-specific proteins) Autoimmune diseases research (Emerging therapies, pathogenic mechanisms, immune tolerance & reset, signaling pathways) Expertise in manipulating immune cells, particularly T cells, including purification, transfection/transduction, activation and expansion, and cryopreservation. Familiarity with markers of memory, exhaustion, and activation for phenotyping of CAR-T cells by flow cytometry. Expertise in immune cell assays including multiparameter flow cytometry, in vitro cell based assays (e.g. cytotoxicity, proliferation, degranulation), live cell analysis (IncuCyte), cytokine measurement (ELISA or Lumit), and multiplex assays. Preferably experience on BD instruments or Cytek Aurora for flow cytometry. Expertise in pseudotyped lentivirus generation by transient transfection. Expertise in basic cell line manipulation, including transient transfection, CRISPR knockout, antigen overexpression, and single cell cloning. Expertise in basic molecular biology techniques, including genomic DNA extraction and qPCR for vector copy number measurement. Familiarity with methods to pre-clinically assess efficacy, specificity, and safety of CAR-T cells or other novel immuno-oncology agents. Familiarity with in vivo models of human cancer, including cell line derived xenografts or patient-derived xenografts. Effective and timely communication of results and relevant scientific literature. Communicate detailed observations on experiments and assist in the preparation of technical reports, summaries, and protocols. Proficient in common software, including GraphPad Prism, Word, PowerPoint, Excel, Outlook, SnapGene, and FlowJo, for data analysis, documentation, and presentation. Commitment to ethical scientific investigations and rigorous experimental methods. Ability and desire to multitask and function in a fast-paced entrepreneurial environment. Interpersonal skills that promote a collaborative and productive lab environment. Effective and efficient written and oral communication skills. Rewards at Arcellx Our people are our greatest asset, and supporting their well-being is an essential part of delivering on our mission and impacting the lives of patients. Putting this belief into practice means offering strong compensation and benefits. The base salary range for this position is $105,000 - $125,000 per year. Where a candidate falls within that range is determined by factors such as years of experience. Our compensation package also includes an annual bonus based on company goals and an equity (RSU) grant. We do offer relocation assistance for roles if required. Our market-leading benefits package includes: 100% coverage for medical, dental and vision for team members and dependents, unlimited vacation, a 3-day weekend every month, fully-paid parental leave for up to 6 months, tuition reimbursement, 401k employer contribution and more. Join us in our quest to reimagine cell therapy and destroy cancer. For more on our technology, culture, and team, go to www.arcellx.com. #LI-Onsite

Responsibilities

As a Scientist, you will contribute to pipeline programs and collaborate with cross-functional teams to generate critical program data. You will design and execute experiments independently and serve as a functional area lead within project settings.