(ID: 2025-0574)
Axle is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations around the globe. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).

TECHNICAL REQUIREMENTS:

• Plan and execute the generation of stable cell lines for preclinical and clinical material production to advance candidates including monoclonal antibodies, recombinant proteins, and virus-like particles.
• Gene synthesis including oligo synthesis, plasmid design, and construction.
• Manage timelines and experimental plans for multiple projects simultaneously and regularly review records of tasks performed by other team members.
• Independently execute and/or manage all steps of the process including plasmid construction, stable pool generation, single cell cloning, and top clone selection.
• Draft and verify data for CMC sections of pre-IND and IND documents to ensure successful registration of candidates.
• Design, perform, and troubleshoot experiments and analyze data for both development and deliverable projects.
• Identify, propose, and execute process and procedural changes to improve performance, robustness, productivity, and efficiency by reviewing recent literature and new technologies.
• Oversee maintenance and support for one or more pieces of laboratory instrumentation.
• Generate, maintain, and review accurate daily records of experiments and results in a laboratory notebook.
• Prepare and review experimental plans, proposals, reports, SOPs, and production records.

SPECIFIC QUALIFICATIONS:

• Ph.D. in Biological Sciences with a minimum of 2 years of experience in an industrial setting focused on the development of stable cell lines for vaccine and biotherapeutic candidates
• Extensive hands-on experience with aseptic technique and mammalian cell culture for the purpose of generating clonally derived cell lines to produce monoclonal antibodies or vaccine candidates
• Demonstrated ability to produce and screen hundreds of clonally derived CHO or 293 cell lines for top performers
• Hands-on experience with multiple supporting technologies for cell line engineering including cell counting, high-throughput transfection, single-cell cloning/deposition, flow cytometry, automated liquid handling systems, and automated small-scale bioreactor systems
• Expertise in designing and constructing plasmids for gene expression using molecular cloning methods
• Ability to independently design experiments and work plans and manage project timelines for multiple complex projects simultaneously
• Experience preparing technical reports, SOPs, data presentations, and documents needed for technology transfer and regulatory filing
  The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment-based age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.
  Accessibility: If you need an accommodation as part of the employment process please contact: careers@axleinfo.com
  Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individual’s assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.
  This role has a market-competitive salary with an anticipated base compensation range listed below. Actual salaries will vary depending on a candidate’s experience, qualifications, skills, and location.

Please refer the Job description for details