Scientist at BPG Bio, Inc

Waltham, Massachusetts, United States -

Full Time

Start Date

Immediate

Expiry Date

05 Sep, 26

Salary

150000.0

Posted On

07 Jun, 26

Experience

5 year(s) or above

Remote Job

Yes

Telecommute

Yes

Sponsor Visa

Skills

MALDI Imaging, Mass Spectrometry, Small Molecule Analysis, Ion Mobility-MS, UHPLC-MS/MS, Sample Preparation, Biomarker Discovery, Data Analysis, Lipidomics, Metabolomics, Proteomics, Organic Chemistry, Cell Biology, Systems Biology, Method Validation, Mentoring

Industry

Biotechnology Research

Description

POSITION SUMMARY The highly motivated Scientist/Senior Scientist will develop and implement advanced MALDI imaging technologies to address important questions in the fields of biology, chemistry, and clinical medicine. This role involves collaborating with a team dedicated to the discovery and validation of biomarkers in diverse disease areas, including neurodegenerative diseases and cancer. ESSENTIAL DUTIES AND RESPONSIBILITIES: * Drive research in qualitative and quantitative MALDI imaging analysis of small molecules (lipids & metabolites), as well as targeted proteins using antibody-based technologies. * Provide robust proof-of-principle and mechanism-of-action imaging data to support internal drug development and/or diagnostic pipelines. * Mentor research associates/scientists and collaborate closely with analytical biochemistry, molecular biology, and computational research staff to design, plan, and perform experiments, collect data, and conduct data analysis. * Communicate findings to a team of chemists, biologists and/or clinicians. * Other duties as assigned. REQUIREMENTS: * Requires a Ph.D. degree in Chemistry, Biology, Biochemistry or a related field with hands-on experience preparing samples for MALDI imaging and operating state-of-the-art HRAM mass spectrometers. Relevant postdoctoral experience preferred. * Ability to develop, optimize, and validate MALDI-based methods (tissue imaging and high-throughput screening on MALDI target plates), including the evaluation of ionization matrices and optimization of mass spectrometric data acquisition strategies. * A strong background in small molecule analysis and ion mobility-MS, and some experience in organic chemistry, cell biology, signaling, and/or systems biology. * Familiarity with sample preparation (liquid-liquid extraction and SPE) and global analysis of lipids and metabolites by UHPLC-MS/MS, including nontargeted (qualitative/semi-quantitative) and targeted (quantitative) analyses, on high-resolution Orbitrap mass spectrometers and triple-quadrupole mass spectrometers. * Ability to work with an interdisciplinary team of biologists, chemists, and computational scientists to deeply characterize and understand the metabolomes, lipidomes and proteomes of cells, biofluids, and tissues. * Demonstrated ability to analyze, interpret, and present data in a clear fashion. * Solid scientific training/productivity as identified through high-impact publications demonstrating creative thinking as well as innovative technical approaches

Responsibilities

Develop and implement advanced MALDI imaging technologies to discover and validate biomarkers for cancer and neurodegenerative diseases. Collaborate with interdisciplinary teams to provide proof-of-principle data supporting drug development and diagnostic pipelines.