Scientist I, Analytical Development and Formulation (CONTRACT) at Entrada Therapeutics

Boston, Massachusetts, United States -

Full Time

Start Date

Immediate

Expiry Date

01 Jan, 26

Salary

0.0

Posted On

03 Oct, 25

Experience

0 year(s) or above

Remote Job

Yes

Telecommute

Yes

Sponsor Visa

Skills

Analytical Methods, HPLC, LCMS, Oligonucleotide Chemistry, Peptide Chemistry, Formulation, Aseptic Handling, Documentation, Collaboration, Communication, Experimental Design, Data Interpretation, Technical Reporting, Laboratory Safety, Problem Solving, Multi-tasking

Industry

Biotechnology Research

Description

The Organization What's happening at Entrada Therapeutics? Entrada is a clinical-stage biopharmaceutical company aiming to transform the lives of patients by establishing a new class of medicines that engage intracellular targets that have long been considered inaccessible. Our Endosomal Escape Vehicle (EEV™)-therapeutics are designed to enable the efficient intracellular delivery of a wide range of therapeutics into a variety of organs and tissues, resulting in an improved therapeutic index. Through this proprietary, versatile and modular approach, Entrada is advancing a robust development portfolio of RNA- and protein-based programs for the potential treatment of neuromuscular and ocular diseases, among others. Our lead oligonucleotide programs are in development for the potential treatment of people living with Duchenne who are exon 44, 45, 50 and 51 skipping amenable. Entrada has partnered to develop a clinical-stage program, VX-670, for myotonic dystrophy type 1. We are a tight-knit team of experts and leaders in both therapeutic development and rare diseases and are excited to grow and attract colleagues who are ready to join a high-energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families. The Perfect Addition to Our Team You are a highly motivated and dependable Scientist who thrives in a collaborative and fast-paced environment. The ideal candidate is detail-oriented with a strong work ethic and possesses strong communication skills with cross-functional stakeholders. The Opportunity In this role, the ideal candidate will be responsible for the analysis and formulation of oligonucleotides/peptides/conjugates/other novel molecules, documenting experiments, and coordinating timelines with internal teams. They will manage the chemical inventory and maintain a good experimental record in electronic lab notebooks. They are expected to interpret and present research data and findings in internal scientific meetings as well as prepare procedures and technical reports. Responsibilities Develop and optimize analytical methods for analysis of oligonucleotide/peptide/conjugates and other novel modalities. Work closely with material generation team to perform in-process control and release tests using techniques such as HPLC and LCMS. Coordinate with internal stakeholders to ensure that materials are available for maintaining the project timeline. Formulate and characterize oligonucleotide/peptide/conjugates and other novel modalities for in vitro and in vivo studies to support discovery projects. Support in-house stability studies. Maintain and troubleshoot analytical instruments to ensure high performance. Coordinate with cross-functional teams for data and sample transfers. Organize and document all experimental data using ELN. Author protocols, standard operating procedures and reports. Contribute to reports and presentations. During internal and external meetings, you should be ready to interpret and present research data and findings. The Necessities At Entrada, our passion for science, our devotion to patients and our values drives our behavior: Humanity - We genuinely care about patients and about one another. Tenacity - We are relentless and persistent in the pursuit of developing therapies for patients. Creativity - We are creative problem solvers. Collaboration - We are more than the sum of our parts. Curiosity - We have a growth mindset and push conventional thought and theory. To thrive on our team, you will need to come with: PhD (0+ years relevant experience) or MS degree (5+ years relevant experience) in Pharmaceutical Sciences, Chemistry, or a related field Hands-on experience and strong knowledge of HPLC (e.g., SEC, IEX, HIC), LCMS and other analytical techniques is required. Understanding of laboratory safety and best practice is required. Experience with analytical method development is a plus. Experience with formulation is a plus. Experience with aseptic handling techniques is a plus. Attention to detail and the ability to thoroughly document experimental work in electronic lab notebooks (ELNs). Understanding of oligonucleotide/peptide chemistry as well as the knowledge of analytical chemistry is a plus. Excellent written skills to author SOPs and technical reports, and verbal communication skills to present internally and externally. To be effective on our team, you must have the ability to interact effectively in a multi-disciplinary, fast-paced research environment as well as the ability to multi‐task to meet research and development goals. This role is a one-year contract position with the possibility of extension depending on business needs. #LI-Onsite Equal Opportunity Employer Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law. Third Party Staffing Agencies Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes. Privacy Statement Entrada Therapeutics, Inc. (the “Entrada,” “we,” “us,” or “our”) respects your privacy and we want you to be familiar with how we collect, use, share, or otherwise process, your Personal Information. Please reference our privacy statement here to understand how and when your data is being used.

Responsibilities

The candidate will be responsible for the analysis and formulation of oligonucleotides, peptides, and other novel molecules, while documenting experiments and coordinating timelines with internal teams. They will also manage chemical inventory and maintain experimental records in electronic lab notebooks.