Scientist I, Immunology at Vividion Therapeutics, Inc

San Diego, California, United States -

Full Time

Start Date

Immediate

Expiry Date

05 Sep, 26

Salary

125000.0

Posted On

07 Jun, 26

Experience

10 year(s) or above

Remote Job

Yes

Telecommute

Yes

Sponsor Visa

Skills

qPCR, CRISPR, Western Blot, ELISA, Flow Cytometry, Immunocytochemistry, Cell Biology, Molecular Biology, Immunology, Cloning, siRNA/shRNA Transfection, AlphaLISA, MSD Assay, T Cell Assays, Assay Development, Target Validation

Industry

Biotechnology Research

Description

Description Company Overview: Vividion is a next generation biotechnology company based in San Diego that is leveraging its proprietary chemical proteomics platform to conduct proteome-wide footprinting of drug-protein interactions with unprecedented breadth and precision. Our technology allows us to screen, identify and optimize novel drugs that selectively bind virtually any protein, including proteins previously considered “undruggable”. Our pipeline and emerging programs reflect a matured and productive platform capable of delivering first in class drugs utilizing novel mechanisms of action (allosteric inhibitors, protein-protein interaction inhibitors, functional activators, degraders etc.) against undruggable targets in the oncology and immunology space. We prize scientific excellence, creativity, team players and we are committed to continued innovation. We have worked hard to create a collaborative and dynamic work culture where your ideas and discoveries are valued and will have an impact. We are growing and there are opportunities for mentorship and career progression. Vividion has been recognized as a Top Workplace by The San Diego Union-Tribune from 2022 to 2025. Job Summary: The successful candidate will have extensive hands-on experience with standard cell biology, molecular and immunological techniques (qPCR, cloning, CRISPR Knock-out/knock-in, western blots, primary cell, immune cell and cell line-based assays, flow cytometry, ELISA, Immunocytochemistry (ICC)). This position will be responsible for executing towards the validation of multiple novel drug targets via a variety of mechanisms, including generating appropriate knockout and knock-in in cells, testing the effects of tool compounds on proteins in cellular and biochemical settings, and the use of Vividion’s proprietary chemical proteomics platform. Requirements Education and Experience requirements: BS/MS with 10+ years OR PhD with 0-2 years’ experience in molecular biology, cellular biology, immunology or a related field Expertise in use of various biology techniques including qPCR, CRISPR (Knock-out and knock-in), siRNA or shRNA transfection, Western blot, ELISA, AlphaLISA and MSD assay Experience in validating and executing cellular assays using primary cells or cell lines to test the activity of compounds Experience in assay development for compound screening and mechanism of action studies Proficiency in T cell assays and Immunocytochemistry (ICC) is preferred Ability and independency to research literature and present ideas/data to support target validation or compound testing Pay & Benefits: The anticipated annual base salary for this position ranges from $115,000 to $125,000 depending on relevant skills, experience, and education. In addition, this position is eligible for target bonus, long-term-incentives, 401k retirement savings plan with company match, and a comprehensive benefits package which includes medical, dental, vision, life, and disability insurance. EEO & Employment Eligibility: Vividion Therapeutics, Inc. is an equal opportunity employer. All applicants will receive consideration for employment without regard to disability or veteran status. Privacy Policy: The protection of your personal information is a commitment we take seriously. For information regarding our Privacy Policy (CA candidates) please visit https://vividion.com/publication/privacy-noticeforcalifornia-candidates/.

Responsibilities

The role involves validating novel drug targets using molecular and immunological techniques, including CRISPR knock-out/knock-in and cellular assays. The scientist will test tool compounds and utilize a proprietary chemical proteomics platform to support drug discovery.