Scientist II, Immunology at Marengo Therapeutics Inc

Cambridge, Massachusetts, United States -

Full Time

Start Date

Immediate

Expiry Date

03 Jun, 26

Salary

0.0

Posted On

05 Mar, 26

Experience

2 year(s) or above

Remote Job

Yes

Telecommute

Yes

Sponsor Visa

Skills

In Vitro Immunology, Cell-Based Assays, Primary Human Immune Cells, Rodent Immune Cells, NHP Immune Cells, Flow Cytometry, Immunoassays, ELISA, MSD, Data Analysis, Experimental Design, Scientific Leadership, Cell Isolation, FlowJo, GraphPad Prism

Industry

Biotechnology Research

Description

Description This is a full-time, onsite role based in Cambridge, MA. Given the hands-on, collaborative nature of this position, we are not considering remote, hybrid-remote, or relocation candidates at this time. Only applicants currently living within commuting distance of Cambridge, MA will be considered. Company Overview Marengo Therapeutics is developing first-in-class immune activators that stimulate and expand anti-tumor T cells to generate deep, durable anti-tumor immunity. The company’s lead program is progressing toward IND in multiple solid tumor indications, supported by an advanced antibody discovery platform and a growing pipeline of multispecific immune-modulating therapeutics. Position Summary We are seeking a highly motivated Scientist II with strong in vitro immunology expertise to join our dynamic research team. In this collaborative role, you will design and execute innovative cell-based assays to support the development of next-generation biologics. You will work with primary human, rodent, and NHP immune cells to assess target engagement, immune activation, cytotoxicity, and mechanistic function using advanced flow cytometry and complementary immunoassay platforms. This position offers the opportunity to contribute directly to pipeline programs, present scientific insights across the organization, and influence the direction of ongoing research through high-quality data generation and scientific leadership at the bench. Key Responsibilities · Design, optimize, and execute in vitro and ex vivo cellular assays leveraging primary human, murine, and NHP immune cells. · Apply advanced flow cytometry and immunoassay methodologies (e.g., ELISA, MSD) to characterize immune cell activity and biologic mechanisms of action. · Analyze complex, multi-parameter datasets; prepare clear, concise technical reports; and present findings to scientific teams and cross-functional stakeholders. · Proactively contribute new experimental ideas and provide scientific insight to support program strategy and decision-making. · Collaborate closely with team members to support murine tissue processing and joint research activities. · Maintain exceptional laboratory practices, including accurate electronic notebook documentation and routine instrument and lab maintenance. · Uphold high standards of communication, organization, and teamwork within a fast-paced research environment. Requirements Required · PhD in Immunology, Cell Biology, or a related discipline with 2+ years of relevant experience, or MS with 6+ years of hands-on immunology experience. · Demonstrated experience executing immunological assays and working with primary immune cells. · Strong proficiency in data analysis and interpretation. · Working knowledge of Microsoft Office and standard scientific software. Preferred · Expertise in immune cell isolation (including magnetic separation methods). · Experience developing and validating primary and immortalized cell-based assays. · Hands-on proficiency with multi-parameter flow cytometry, immunoassays, and cell culture. · Experience with analytical tools such as FlowJo and GraphPad Prism. · Prior experience in biopharmaceutical R&D or drug development.

Responsibilities

The Scientist II will design, optimize, and execute innovative in vitro and ex vivo cellular assays using primary immune cells to assess target engagement and mechanism of action for next-generation biologics. This involves applying advanced flow cytometry and immunoassay platforms, analyzing complex datasets, and presenting scientific insights to guide research direction.