Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting-edge therapeutics for patients worldwide.
Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel). Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.
Legend Biotech is seeking Scientist II - In Vivo Pharmacology as part of the Research & Early Development team based in Philadelphia, PA.

REQUIREMENTS

• Master’s or bachelor’s degree in biological sciences (Immunology, cell biology and cancer biology) or related area
• At least Five years’ laboratory experience. Extensive hands-on in vivo study experience is required. Expertise in various injections, especially in tail vein injection, bleeding, in vivo imaging, tissue collection and processing.
• Extensive experience in execution of T cell functional analysis and multi-color flow cytometry assays is required.
• Molecular biology skills such as DNA and RNA extraction, RT-PCR and ddPCR, etc.
• Prior experience in CAR-T/NK cell therapy development is preferred. Experience in lentivirus production is a plus
• Sense of ownership and integrity of their work. Demonstrated ability to work as part of a team
• Demonstrated organizational skills including but not limited to pay attention to details and multitasking
• Biotech or pharmaceutical industry experience is preferred.
• Expertise in in vivo and in vitro studies, excellent mouse tail vein injection skill, flow cytometry, ELISA, tissue culture/primary cell culture, cytotoxicity assays, qPCR, and multiplexed cytokine analysis assays (MSD and Luminex).
• Excellent verbal and written communication skills in English
  

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ROLE OVERVIEW

This position will perform preclinical in vivo pharmacology and toxicology studies to support pipeline programs. The ideal candidate will have experience in immunology or immune-oncology and in vivo studies with animal models. The successful candidate will work in a collaborative environment and is skillful in driving multiple projects by contributing to the development of cell-based immunotherapies.

KEY RESPONSIBILITIES

• Work together with other team members to plan, design and execute in vivo studies with mice and NHP; process and analyze various samples, including blood, tumor and tissues from mice and NHP
• Manage mouse colonies, maintain instruments in animal facility for example IVIS imagine machine
• Cell culture and immune cell functional analysis in vitro and in vivo
• Interact with research teams for collaboration
• Participate in assay development and qualification