WORKING WITH US

Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us .
The Oncology Thematic Research Center at BMS is a key research and early development engine, responsible for the discovery and development of novel oncology therapeutics for patients. Centered at our state-of-the-art research sites in Cambridge and Seattle, scientists focus on novel targets and pathways for tumors that are refractory to current therapies. With a deep understanding of the causal human biology, we are able to leverage our multiple modality platforms to best match the modality to the mechanism and desired outcome. We are a fully integrated drug discovery through translational and early clinical development organization which exploits state-of-the-art in vitro, in vivo and ex-vivo models of Cancer biology and Immuno-oncology to identify and validate targets. We partner closely with colleagues in Translational Medicine, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials. We are optimally positioned to complement the world-class translational expertise, biology and leading academic research centers in the area.
Our Bristol Myers Squibb research site in Cambridge Crossing will help us continue to deliver on our mission, positioning the company and our scientists in the heart of a vibrant ecosystem of world-class science, innovation, and business opportunities.

POSITION OVERVIEW:

We are seeking a highly motivated, experienced and talented Scientist to join our Discovery Biosciences team. This individual will play a key role in advancing our oncology drug discovery programs, with a focus on cancer immunology and next-generation biotherapeutic targets identification, validation, mechanism of action and drug resistance studies. This position is heavily focused on wet lab work, contributing to cutting-edge research projects aimed at understanding cancer biology, identifying novel drug targets, and developing new therapeutic approaches. The successful candidate will bring deep scientific expertise, creative problem-solving skills and a collaborative mindset to drive impactful research.

Basic Qualifications:

• Bachelor’s Degree
• 5+ years of academic and / or industry experienc

Preferred Qualifications:

• Extensive experience in oncology research, with background in cancer immunology and/or biotherapeutics (eg. ADCs, multispecifics, and TCEs) is strongly preferred
• Proven track record with designing and developing a variety of biochemical and cellular assays
• Hands on experience with functional genomics, CRISPR screens, high content imaging, flow cytometry, RNA-seq and proteomics is highly desirable
• Proficiency in data analysis software (e.g., GraphPad Prism, FlowJo) and familiarity with bioinformatics tools
• Effectively troubleshooting skills when optimizing assays and when developing innovative methodologie

In the role as a Scientist within the Discovery Biosciences team, the ideal candidate will:

• Conduct full time laboratory-based research supporting target identification, oncology drug discovery and development
• Strong biology skills with experience using a wide range of cellular and molecular biology techniques, 2D and 3D cell culture and manipulation of complex cellular model systems (organoid, immune and stromal cell co-culture, and cancer cells), flow cytometry, qPCR, cell proliferation assays, generating reporter assays, molecular cloning techniques, western blotting, immunoprecipitation, ELISA, MSD
• Strong experience developing and applying state-of-the-art gene perturbation methods (siRNA/shRNA knockdown, nucleofection, and CRISPR-mediated genome editing)
• Design, optimize, and troubleshoot complex cell-based assays to evaluate therapeutic candidates and understand cancer signaling pathways and drug resistance
• Collaborate with cross-functional teams, including medicinal chemistry, bioinformatics, and in vivo pharmacology, to advance project goals
• Analyze and interpret experimental data, maintain accurate and detailed lab records, and present findings in team meetings
• Contribute to the preparation of technical reports, publications, and presentations

Basic Qualifications:

• Bachelor’s Degree
• 5+ years of academic and / or industry experience

Or

• Master’s Degree
• 3+ years of academic and / or industry experience

Or

• Ph.D. or equivalent advanced degree in the Life Sciences
• No experience necessary

Preferred Qualifications:

• Extensive experience in oncology research, with background in cancer immunology and/or biotherapeutics (eg. ADCs, multispecifics, and TCEs) is strongly preferred
• Proven track record with designing and developing a variety of biochemical and cellular assays
• Hands on experience with functional genomics, CRISPR screens, high content imaging, flow cytometry, RNA-seq and proteomics is highly desirable
• Proficiency in data analysis software (e.g., GraphPad Prism, FlowJo) and familiarity with bioinformatics tools
• Effectively troubleshooting skills when optimizing assays and when developing innovative methodologies

LI-Onsite

If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.