ABOUT THE COMPANY

Oxford StemTech is a dynamic and innovation-driven biotechnology company with expertise in cellular reprogramming and induced pluripotent stem cell (iPSC) technologies for neuroscience drug discovery.
We are seeking a motivated candidate for the Scientist position, responsible for in vitro neuronal disease modelling, with emphasis on iPSC-derived trigeminal peptidergic nociceptors. This is a two- year position with a three-month probationary period, with the possibility of extension. The candidate will work closely with and report directly to the Chief Scientific Officer and the Director.

REQUIRED QUALIFICATIONS AND EXPERIENCE

• Master’s with > 4 year work experience or PhD in Neuroscience or related field.
• Proven expertise in iPSC differentiation protocols to generate neurons, as well as in vitro disease modelling techniques.
• Strong background in neuronal functional assays such as electrophysiology, calcium imaging, live-cell imaging, ELISAs.
• Proficient in cellular and molecular biology techniques, including immunostaining, qPCR, flow cytometry.
• Proficient in data analysis using relevant software and statistical tools.
• Excellent communication skills and ability to work collaboratively in a research team.

DESIRED SKILLS

· Prior experience working in an industry setting
· Experience in complex in vitro models of iPSC-based functional assays
· Demonstrated experience working with multi-electrode array platform
· Published research findings in peer-reviewed journals is a plus
· Experience with gene transfection, CRISPR assays and stable cell line generation
· Excellent organisational and project management skills

• Lead efforts on the iPSC-derived Trigeminal Peptidergic Nociceptor Project: Prioritise and execute research activities focused on disease modelling and target validation relevant to client and internal research objectives.
• iPSC Differentiation: Direct differentiation of human iPSCs into disease-relevant neuronal subtypes for use in neuroscience drug discovery.
• Drug Discovery Assays: Develop and perform assays, assessing the efficacy and mechanism of action of candidate compounds - specific emphasis on Multi-Electrode array (MEA), ELISA, and Calcium imaging.
• Data Analysis: Analyse, interpret, and present experimental results with scientific rigour and clarity.
• Collaborative Research: Work collaboratively with cross-functional research teams on additional scientific projects, supporting the broader mission of the company.
• Scientific Engagement: Stay up to date with scientific developments in iPSC differentiation, neurobiology, and drug discovery, integrating relevant findings into research strategy.