Scientist, Protein Expression at Anthology

Cambridge, Massachusetts, United States -

Full Time

Start Date

Immediate

Expiry Date

22 Aug, 26

Salary

0.0

Posted On

25 May, 26

Experience

2 year(s) or above

Remote Job

Yes

Telecommute

Yes

Sponsor Visa

Skills

Molecular Cloning, Protein Expression, Fungal Transformation, SDS-PAGE, Western Blot, ELISA, Assay Development, Microfluidics, Bioinformatics, Python Scripting, Protein Design, Genetic Assembly

Industry

Biotechnology Research

Description

Scientist - Protein Expression (Full-Time) Location: Cambridge, MA (On-site) Company: Anthology Bio Company summary Anthology is Boston-based genome design company. We engineer fungi through advanced genetics, microfluidics, and AI to biomanufacture functional proteins at 5-10× lower cost compared to extracting these proteins from their natural sources. Our goal is to build a climate-resilient protein supply chain for human and planetary health. Backed by leading deep-tech investors, we have partnered with global nutrition and ingredient manufacturers to bring cost-effective proteins to market. Overall: We are looking for a hands-on scientist to drive recombinant protein expression in filamentous fungi. Reporting to the Director of R&D, you will own the bench work that sits at the core of our platform, from cloning and fungal transformation through expression screening and assay development. You will also collaborate closely with our microfluidics team to push protein screening into high-throughput microdroplet formats. This is a role for someone who is equally comfortable designing experiments and troubleshooting them at the bench. Responsibilities: Design and execute molecular cloning workflows to construct and optimize fungal expression vectors Perform fungal transformation and develop efficient DNA delivery protocols in target strains Develop and run protein expression assays in shake flask format, from culture setup through quantification and characterization Work with the microfluidics team to adapt and validate protein assays for microdroplet-based high-throughput screening Mine and characterize genetic parts (e.g. signal peptides) to expand our engineering toolkit Maintain rigorous experimental documentation to support reproducibility and platform iteration Qualifications: PhD in bioengineering, microbiology, biochemistry, or a related field Strong molecular cloning skills and experience constructing complex genetic assemblies Experience with protein expression and characterization including SDS-PAGE, western blot, ELISA, or equivalent assays Able to work on-site in Cambridge, MA Authorized to work in the United States (STEM-OPT or J1 are welcomed) Nice to have Direct experience culturing and/or engineering filamentous fungi (Aspergillus, Trichoderma, or similar) Familiarity with protein design using biological language models (ESM, ProteinMPNN, RFdiffusion, or similar) Python scripting experience — data processing, assay analysis, or bioinformatics workflows Why work at Anthology? Work on a genuinely hard, open-ended problem — fungal expression biology at the frontier of what's commercially relevant Collaborate across wet lab, microfluidics, and computational teams in a highly integrated environment Brand-new 150K sq ft deep-tech facility at The Engine by MIT Competitive salary, equity, and benefits Start Date: ASAP

Responsibilities

Drive recombinant protein expression in filamentous fungi through cloning, transformation, and assay development. Collaborate with the microfluidics team to implement high-throughput protein screening in microdroplet formats.