Scientist / Sr Scientist / Staff Scientist - Antibody Platform Development at TWIST BIOSCIENCE CORPORATION

South San Francisco, California, United States -

Full Time

Start Date

Immediate

Expiry Date

06 Apr, 26

Salary

180000.0

Posted On

06 Jan, 26

Experience

2 year(s) or above

Remote Job

Yes

Telecommute

Yes

Sponsor Visa

Skills

Antibody Development, Molecular Biology, Cell Culture, Automation, Analytical Techniques, Protein Expression, Purification, Analytics, Bispecific Antibodies, Stable Cell Lines, Vector Design, High-Throughput Workflows, Antibody Characterization, Python, Liquid-Handling Systems, Method Development

Industry

Biotechnology Research

Description

Scientist / Sr Scientist / Staff Scientist - Antibody Platform Development (South San Francisco, CA) Job Description Twist is searching for a curious, thoughtful, and driven RnD scientist with excellent lab hands to enhance our antibody development platform development efforts. You will use your deep scientific experience and knowledge in various antibody and antibody-like modalities to as well as expertise in molecular biology, cell culture, automation, and analytical techniques to create and improve platform technologies for antibody discovery, development and transition to the clinic. We are looking for people who have deep technical knowledge and a strong drive to get things done. Job title and compensation will be determined based on several factors, including but not limited to the candidate's years of experience, individual skills, knowledge, and abilities. Key Responsibilities: Develop antibody production, purification and analytical workflows at various scales and throughput, across various formats (single-chain, IgG, multi-specific, Fc-Fusion, etc). Optimize all aspects of the end-to-end antibody development workflow including but not limited to: construct design, protein expression (transient and stable), purification, and analytics Independently design and execute experiments, and analyze experimental data As appropriate, build and lead a team to achieve technical goals Move projects forward efficiently / manage time and resources effectively / prioritize tasks in accordance with the company’s goals Document and communicate results clearly and succinctly Be helpful / collaborative / proactive Stay up to date with new developments, companies, and technologies Be the ultimate subject matter expert, and understand all aspects of your work as profoundly as possible, including details that are adjacent to your projects What You’ll Bring to the Team: Deep hands-on experience designing, expressing, and optimizing monoclonal antibodies, with demonstrated understanding of Fc structure–function relationships (effector function, stability, manufacturability). Proven experience with bispecific antibody architectures, including but not limited to: Knob-in-hole, CrossMab, common light chain, or similar Chain pairing control, mispairing mitigation, and associated analytics Extensive experience generating and optimizing stable mammalian cell lines (CHO preferred): Vector design, promoter/selection strategies Clone screening, productivity optimization, and stability assessment Strong understanding of transient vs stable expression tradeoffs and when to deploy each during platform development. Experience improving expression yields and product quality through sequence, vector, and host engineering. Demonstrated ability to build, improve, and standardize antibody generation workflows. Experience developing high-throughput or semi-automated workflows for expression, purification, and screening. Strong understanding of platform robustness, reproducibility, and cost drivers. Hands-on experience with antibody characterization methods, including but not limited to: SEC, CE-SDS Binding kinetics (BLI or SPR) Basic biophysical profiling (DSF, DLS) Mass spectrometry Strong mechanistic understanding of antibody biology, structure, and expression bottlenecks Experience designing platforms that support multiple antibody modalities (mAbs, bispecifics, Fc-engineered variants) A track record of successful and creative method development Familiarity with Python or equivalent programming languages is a plus Experience with liquid-handling systems and automation is a plus Qualifications: Advanced degree in Cell Biology, Biochemistry, Chemical Engineering, or a closely-related field Scientist Requires a PhD and 0-2 years of previous professional experience; or a master's degree and 3-5 years of work experience Sr Scientist Requires a Ph.D. and 3-5 years of professional experience (postdoc may count); or a master's degree and 7+ years of work experience Staff Scientist Requires a Ph.D. and 6-10 years of professional experience (postdoc may count); or a master's degree and 10+ years of work experience About Twist Bioscience Twist Bioscience synthesizes genes from scratch, known as “writing” DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA. At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers. Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law. The base cash compensation for this California-based role is below. In addition to base salary, this role is eligible for bonus, equity, and a generous benefits package. Final compensation amounts are determined by multiple factors, including candidate skill, experience, expertise, and location and may vary from the amount listed above. Compensation may be different in other locations. San Francisco Bay Area Pay Range $127,000—$180,000 USD

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Responsibilities

Develop and optimize workflows for antibody production, purification, and analytics. Independently design experiments and manage projects to achieve technical goals.