Senior Analytical Scientist (Method Development & Platform Innovation) – Co at Public Service Division

Aberdeen City, Scotland, United Kingdom -

Full Time

Start Date

Immediate

Expiry Date

11 Jul, 26

Salary

0.0

Posted On

12 Apr, 26

Experience

5 year(s) or above

Remote Job

Yes

Telecommute

Yes

Sponsor Visa

Skills

Bioassay development, Monoclonal antibodies, Surface Plasmon Resonance, Biolayer Interferometry, High-Resolution Mass Spectrometry, Physicochemical characterisation, Peptide mapping, Glycan profiling, Method validation, ICH Q2 guidelines, ISO17025, Project management, Data analysis, Chromatographic techniques, Statistical software

Industry

IT Services and IT Consulting

Description

[What the role is] To lead the development, optimization, and validation of bioassays and advanced analytical methodologies to support the regulatory testing of monoclonal antibodies (mAbs) and next-generation formats (ADCs, bispecifics, scFvs, AOCs etc.) to ensure the quality and safety of innovator and biosimilar products in the market. [What you will be working on] Technical Excellence & Method Development: Lead bioassay development for monoclonal antibodies and next-generation complex formats (ADCs, bispecifics, scFvs, AOCs etc.) that reflect functionality including ADCC/CDC assays, dual-target engagement, payload-mediated cytotoxicity, and chain-pairing analysis. Develop and validate analytical methods using advanced techniques including Surface Plasmon Resonance (SPR) and Biolayer Interferometry (BLI) for complex binding interactions and High-Resolution Mass Spectrometry (HRMS) for structural characterisation, Drug-to-Antibody Ratio (DAR) determination and conjugation site analysis. Establish platform capabilities for physicochemical characterisation including peptide mapping, glycan profiling, post-translational modification analysis, charge variant assessment, and conjugate characterisation that can be applied across different biologics classes. Drive method transfers from research laboratories to regulatory testing facilities, ensuring robust validation according to ICH Q2(R1/R2) and relevant guidelines. Support laboratory transformation initiatives including integrating AI and automation tools to enhance productivity, identifying capability gaps for emerging biologics formats, and proposing actionable improvement plans for next-generation testing requirements. Consultancy & Leadership Provide expert scientific opinions related to biologics testing to clients and stakeholders. Evaluate training programs and provide technical guidance to the team to enhance lab testing capability. Represent the laboratory to present the research and development findings at local and international conferences, meetings and professional forums. Quality & Safety Prepare comprehensive validation reports and technical documentation to support method implementation in the laboratory. Support laboratory accreditation activities according to ISO17025 standards. Assist in administrative tasks to ensure smooth laboratory operations. [What we are looking for] Education & Experience: Strong background in Life Sciences, Biomedical Sciences, Biochemistry, or relevant scientific disciplines. Minimum 7 years of laboratory experience for biologics testing and method validation. Experience with characterisation and bioassay development for monoclonal antibodies or next-generation complex formats (ADCs, bispecifics, scFvs, AOCs etc.) preferred. Technical Skills: Hands-on experience with cell-based bioassays, particularly proliferation assays, reporter gene systems, ADCC/CDC effector function and cytotoxicity assays. Proficiency in Biolayer Interferometry (BLI) or Surface Plasmon Resonance (SPR) for binding kinetics assays. Experience with chromatographic techniques (SEC-HPLC, CEX-HPLC, HIC-HPLC) for biologics quality assessment. Working knowledge of LC-MS techniques for protein characterisation, including intact mass, peptide mapping, glycan and PTM analysis. Familiarity with statistical software (GraphPad Prism, R, or similar) for bioassay data analysis and parallel line analysis. Regulatory & Quality Knowledge: Understanding of ICH guidelines for biologics and method validation principles. Knowledge of biosimilar regulatory requirements and comparability studies preferred. Experience with ISO/GLP/GMP laboratory practices preferred. Soft skills: Strong project management abilities with experience coordinating multi-site collaborations. Excellent communication skills for technical reporting and stakeholder engagement. Ability to work independently while contributing effectively to cross-functional teams. Problem-solving mindset with attention to detail in experimental design and data interpretation. http://jobs.careers.gov.sg The Singapore Public Service plays a key role in the economic growth, progress and stability of Singapore by formulating and implementing government policies, as well as providing key public services. Whether you are a fresh graduate joining the workforce or an experienced professional, the Singapore Public Service offers a great variety of job opportunities for you. The work in the Public Service can be broadly categorised into the following sectors: Economic, Social, Security & External Relations, and Administration & Corporate Development. Be part of the team that shapes the future of Singapore. Log on and take your first step towards a career that matters! Need help? Please click here for assistance. Our team will contact you shortly!

Responsibilities

Lead the development, optimization, and validation of bioassays and advanced analytical methodologies for monoclonal antibodies and complex biologics. Provide expert scientific consultancy, drive method transfers, and ensure laboratory compliance with regulatory standards.