YOUR MISSION

Engitix Therapeutics is a pioneering biotech company dedicated to unlocking extracellular matrix biology to develop new therapeutics in fibrosis and oncology. We are seeking an experienced Senior Director of Pharmacology and Assay Development to oversee all aspects of preclinical development for biologic and small molecule drug candidates into clinical development.

ABOUT US

Engitix is a growing biotech company based in White City Place, West London. We are dedicated to developing better therapies for advanced fibrosis and solid tumours by leveraging our pioneering extracellular matrix (ECM) platform. Our platform allows the synthesis of realistic in vitro 3D models that serve as tools to transform our ability to identify new targets and biomarkers, determine mechanisms of action and more accurately predict the efficacy of therapeutic candidates.
Join us today in our mission to create a healthier future for patients with life-threatening diseases such as fibrosis and cancer.

• Lead discovery teams by developing and executing preclinical development strategies for drug candidates, ensuring alignment with the company’s overall R&D and business objectives
• Partner with Engitix scientists and external collaborators to develop preclinical screening strategies for discovery programs. This will include developing and optimizing new assays that will support target validation and/or screening of potential therapeutic candidates. These screening assays may also leverage proprietary Engitix platforms and/or be used to support high content screens (eg, CRISPR)
• Lead cross-functional discovery teams to design, execute, and interpret critical IND-enabling studies, including ADME, pharmacology, toxicology, pharmacokinetics (PK), pharmacodynamics (PD), and immunogenicity assessments. This will include identifying potential risks and developing mitigation strategies for different workstreams
• Oversee and contribute to the preparation of preclinical sections of regulatory documents, including pre-IND meetings, IND submissions, investigator brochures, and briefing packages
• Integrate and optimize automation strategies for handling complex cellular and biochemical assays, increasing the efficiency of hit identification, lead optimization, and mechanistic studies
• Partner with the team to integrate analysis pipelines for cellular- and patient-derived data sets (including transcriptomics, proteomics, and spatial biology) to identify new targets. Provide strategic input into target validation strategies and plans, including evaluation of enabling technologies
• Establish and manage timelines, budgets, and resources for preclinical programs, ensuring efficient and cost-effective execution
• Work closely with Engitix leadership to align project goals with corporate strategy and portfolio priorities