Amphista is a leading biotech applying a pioneering next generation Targeted Protein Degradation technology to the discovery of therapeutics for human diseases. We are advancing programs into the clinical development phase with the aim of bringing transformational medicines to patients, and are seeking an experienced Senior Director of Project & Portfolio Management to join our team. To find out more about us, please visit: www.amphista.com

POSITION:

We are seeking a highly experienced Senior Director of Project & Portfolio Management to oversee Amphista’s portfolio of therapeutic projects. In this pivotal role, you will play a critical part in the successful management and execution of our diverse pipeline, with a particular focus on driving forward our lead drug development project. This is a unique opportunity to have a significant impact on the future of our innovative therapies, working closely with cross-functional teams to ensure the timely delivery of key milestones.

REQUIREMENTS:

• Degree in a relevant scientific discipline.
• Minimum of 10 years of Pharmaceutical or Biotechnology experience.
• Thorough understanding of the drug development process from candidate selection through early clinical development, in a pharma or biotech environment.
• Experience providing project management support to successful drug discovery & development programmes achieving milestones from IND/CTA approval, through to First in Human studies and beyond.
• Experience providing strategic input at R&D portfolio level to allow successful achievement of R&D and corporate goals.
• Direct experience of initiating and managing relationships with external service providers to deliver successful drug development programmes and a strong understanding of how to make such relationships work.
• Experience in delivering high business impacting programme/projects and experience of managing, allocating and tracking significant budgets.
• Solid experience of project planning software.

MORE ABOUT AMPHISTA

Amphista’s approaches use completely novel mechanisms to build on all the advantages of TPD while directly addressing the emerging limitations of existing TPD strategies to expand the utility of the field. We have shown our approach has the potential to be superior to all other TPD approaches (PROTACs, molecular glues etc) improved druglike properties and reduced tumour resistance potential. We have a range of projects in the discovery phase, initially focused on oncology with potential to expand into other therapy areas including CNS disease & immunology.
Initially founded from the laboratory of Professor Alessio Ciulli (University of Dundee) our team comprises both academic and drug discovery pioneers of the TPD field and a growing R&D team focused on advancing a portfolio of medicines to the clinic using our proprietary next generation TPD technologies. We are continuing to grow and are looking for a key hire to expand our screening and assay teams.
The Amphista team comprises highly experienced drug discovery and TPD experts across both biology and chemistry disciplines, creating the ideal learning environment to advance your scientific career development quickly. This is an exciting opportunity to join a fast growing and dynamic company operating at the cutting edge of protein degradation-based drug discovery to develop first-in-class medicines to treat cancer and other areas of high unmet medical need

• Contribute to strategic direction of the project and help drive tactical delivery plan.
• Maintain a project plan to deliver to key project milestones and which encompasses detailed timelines, budget and resource forecasts, and interdependencies.
• Identify key bottlenecks and risks to delivery and propose mitigation strategies.
• Propose opportunities to optimise plans & processes to accelerate the project or improve quality of deliverables.
• Engage and manage relationships with external service providers as required to support key components of the project plan.
• Work closely with the project team, internal functions and external service providers to coordinate delivery and identify deviations from plan in terms of timelines, budget and risk profile.
• Responsible for management of project team meetings and chairing these where needed.
• Support drug discovery project teams in construction and maintenance of project plans with timeline, budget and resource forecasts.
• Work with discovery project teams to track changes in project plan and flag budget and timeline changes.
• Work with finance function to provide leadership team with accurate and clear budget forecasts and expenditure for the R&D portfolio, which will include:
• Budgetary oversight and forecasting for whole R&D portfolio
• Contribute to the implementation of new systems to track and manage R&D budgets and timeline
• Provide support for business development activities and investor interactions as needed