Senior/Executive Director, Clin Pharmacology at AVENZO THERAPEUTICS INC

San Diego, California, United States -

Full Time

Start Date

Immediate

Expiry Date

24 Jul, 26

Salary

328200.0

Posted On

25 Apr, 26

Experience

10 year(s) or above

Remote Job

Yes

Telecommute

Yes

Sponsor Visa

Skills

Clinical pharmacology, Pharmacokinetics, Pharmacodynamics, Exposure-response analysis, Oncology, Regulatory submissions, IND, NDA, Clinical study design, Data analysis, Modeling, Vendor management, Cross-functional leadership, Strategic planning, Communication, Problem-solving

Industry

Biotechnology Research

Description

Job Title: Senior Director/Executive Director, Clinical Pharmacology Location: San Diego, California or Remote U.S. Job Type: Full-Time Who We Are Avenzo Therapeutics, Inc. (“Avenzo” or “Company”) is a clinical-stage biotechnology company focused on developing next-generation oncology therapies for patients. The Company was co-founded in 2022 by Drs. Athena Countouriotis and Mohammad Hirmand (former CEO and CMO of Turning Point Therapeutics, Inc., respectively). With a proven track record in building and scaling biotech companies, our experienced management team is passionate about and committed to building a pipeline of potential best-in-class targeted oncology programs. The Company is headquartered in San Diego, California. Position Summary Reporting to the Vice President, Clinical Pharmacology, the Senior Director/Executive Director, Clinical Pharmacology will help lead the design, analysis, and interpretation of clinical pharmacology strategies across our development programs. This role is ideal for a scientific leader who thrives on rolling up their sleeves, working closely with data, and directly influencing clinical and regulatory outcomes. Essential Job Functions and Responsibilities * Design and oversee pharmacokinetic (PK), pharmacodynamic (PD) and exposure-response analyses to support dose selection, study design, and benefit-risk assessments * Propose and lead the development and execution of clinical pharmacology components of studies * Provide scientific leadership for the clinical pharmacology components of clinical studies (including early-phase studies) from protocol concept through analysis, interpretation, and decision making * Author, review, and approve clinical pharmacology content for regulatory submissions (e.g., INDs, CTAs, NDAs/MAAs, briefing packages) and support health authority interactions * Collaborate with internal/external modeling experts to design and oversee population PK, exposure–response, and related analyses; ensure quality, interpretability, and timely delivery of outputs * Serve as the clinical pharmacology lead on cross-functional program teams; translate pharmacologic insights into clear recommendations and influence program governance and development strategy * Define analysis plans and interpretation frameworks for PK/PD data (including model-informed drug development approaches) and ensure alignment with global regulatory expectations for small-molecule therapeutics * Provide clinical pharmacology expertise to the project team and closely collaborate with Clinical Operations, Clinical Research, Biometrics, and Bioanalysis * Contribute to program-level planning and prioritization based on pharmacological insights and development risk * Accountable and responsible for the analysis and interpretation of PK and PK/PD data Preferred Qualifications * PhD required, advanced medical or life sciences or a related area degree preferred (e.g., MD, Pharm.D.) with 12+ years of experience in the life sciences industry or an equivalent combination of academic and industry experience * Direct experience designing and executing early-phase clinical studies, including healthy volunteer studies * Strong expertise in PK analysis and exposure-response interpretation; experience in oncology preferred * Experience managing external Clinical Pharmacology resources * Proven track record of contributing to regulatory submissions and engaging with health authorities * Familiarity with all stages of clinical drug development, including prior experience in the preparation of components of the Clinical Pharmacology sections of Regulatory submissions for IND- and NDA-stage projects * Demonstrated ability to independently develop clinical pharmacology strategy and design studies to characterize PK and PK/PD relationships of clinical development compounds * Expertise/experience in multiple clinical pharmacology areas is preferred * Extensive experience in preparation of INDs, CTAs, NDAs, and MAAs as well as successful results from the filings * Experience in working in a cross functional team/matrix environment with strong vendor management skills * Competent in the use of PK and PK/PD Modeling software tools * Excellent communication and interpersonal skills, with the ability to collaborate effectively with internal and external stakeholders * Strong analytical and problem-solving abilities, with a strategic mindset * This position requires periodic/regular travel, including up to 15% of work time, which may include overnight travel Physical Demands and Work Environment Physical Demands: * Constant or continuous use of a computer keyboard, monitor, and mouse to perform a variety of tasks * Constant or frequent sitting, standing, or walking * May lift and/or move objects of various weights Work Environment: * San Diego-based: On-site requirement (Monday through Thursday) * Remote: Home office; expected to travel to and work from the Company’s headquarters in San Diego from time to time * Noise level in the work environment is usually moderate * Fast-paced, time sensitive environment with frequently changing priorities * Handle multiple projects simultaneously Reasonable accommodations may be provided to enable qualified individuals with disabilities to perform the essential functions of the position. Salary Range The salary range for this position for a Senior Director is $290,300 to $301,200 per year and for an Executive Director $318,100 to $328,200 per year. The final pay offered to a successful candidate will be dependent on several factors that may include, but are not limited to, the type and years of experience within the job and the industry, education, and skills and certifications. Benefits Provided they meet all eligibility requirements under the applicable plan documents, employees (and their eligible dependents) will be eligible to enroll in group healthcare plans that offer medical, dental, vision, and basic life and AD&D insurance. Additional benefit programs include short-term and long-term disability insurance, flexible spending accounts, health savings accounts, and voluntary insurance programs, including voluntary life, AD&D accident, and critical illness. Employees will also be able to enroll in the Company’s 401(k) plan. In addition, employees will accrue 10 hours of paid vacation time every month or and accrue 1 hour of paid sick leave for every 30 hours worked. Employees also enjoy 17 paid holidays each calendar year, including a winter closure, subject to applicable Company policies. All benefits are subject to the terms and conditions of the applicable plan documents and Company policies, which may be amended from time to time. Other Compensation The hired candidate will be eligible to receive an annual discretionary bonus and an equity award, subject to the terms of the applicable employment agreement, plan documents, and Company policies. The information above is intended to provide a general description of benefits and other compensation and is not a substitute for applicable plan documents or company policies. Applications for this position are anticipated to close on June 30, 2026. For more information about this posting, please contact careers@avenzotx.com [careers@avenzotx.com]. Equal Employment Opportunity Avenzo is committed to providing equal employment opportunities to all employees and applicants without regard to an individual’s actual or perceived protected characteristic or characteristics, or any combination of protected characteristics including race (including traits associated with race, such as hair texture and protective hairstyles, including braids, locks, and twists), ethnicity, religion, religious creed (including religious dress and grooming practices), color, sex (including childbirth, breast feeding, and related medical conditions), gender, gender identity or expression, sexual orientation, national origin, ancestry, citizenship status, uniformed service member and veteran status, marital status, pregnancy, age (40 and over), protected medical condition (including cancer and genetic conditions), genetic information, disability (mental and physical), reproductive health decision-making, medical leave or other types of protected leave (requesting or approved for leave under the Family and Medical Leave Act or the California Family Rights Act), the employee or their family member’s status as a victim of a qualifying act of violence, political activity or affiliation, use of cannabis off the job and away from the workplace, association with an individual who has, or is perceived to have, a protected characteristic or characteristics, or any combination of protected characteristics, or any other protected status in accordance with all applicable federal, state, and local laws. Notice to Search Firms/Third Party Agencies Avenzo does not accept unsolicited resumes from recruiters, employment agencies or search firms without a valid, executed search agreement in place.

Responsibilities

The role involves leading the design, analysis, and interpretation of clinical pharmacology strategies to support oncology development programs. You will oversee PK/PD analyses, contribute to regulatory submissions, and provide scientific leadership across cross-functional teams.