Senior Medical Director, Clinical Development at Olema Oncology

San Francisco, California, United States -

Full Time

Start Date

Immediate

Expiry Date

06 Feb, 26

Salary

350000.0

Posted On

08 Nov, 25

Experience

5 year(s) or above

Remote Job

Yes

Telecommute

Yes

Sponsor Visa

Skills

Oncology, Clinical Development, Study Design, Regulatory Engagement, Data Integrity, Patient-Centric Decision-Making, Biomarker Development, Publication Planning, Collaboration, Leadership, Communication, Problem-Solving, Team Building, Strategic Vision, Adaptability, Detail-Oriented

Industry

Biotechnology Research

Description

Olema Oncology is dedicated to developing better medicines for breast cancer and beyond. Our lead program, palazestrant (OP-1250), is a complete estrogen receptor antagonist (CERAN) currently in development for metastatic breast cancer with blockbuster potential as a monotherapy and in combination in ER+/HER2- metastatic breast cancer. Our follow-on product candidate, OP-3136, is a potent KAT6 inhibitor with best-in-class potential. Our scientific breakthroughs are accelerated through the ways in which we fearlessly support, motivate, and challenge one another. At Olema, we know that when we put people first, our work becomes second to none. If you’re ready to join us at the edge of something unstoppable, let’s make a profound impact together for our patients, for your career, for what’s beyond. You can view our latest corporate deck and other presentations here. As the Senior Medical Director, reporting to the SVP of Clinical Development, you will serve as the Oncology Physician Lead for palazestrant and play a pivotal role in advancing Olema’s late-stage clinical pipeline. You will guide registration-enabling studies by shaping study design, evaluating clinical data, and engaging with regulatory authorities, investigators, and key opinion leaders. Partnering closely with experienced physicians and cross-functional teams, you will ensure scientific rigor, data integrity, and patient-centric decision-making while contributing to biomarker development, publication planning, and external scientific communications. This is a unique opportunity to contribute at a pivotal moment in the program’s trajectory and support the advancement of therapies for patients with ER-positive, HER2-negative breast cancer. This role may be based in either San Francisco, CA or Cambridge, MA and may require up to 20% travel. Key Responsibilities Provide Medical Leadership and Expertise Lead registration-enabling studies for palazestrant in combination with other therapies, including study design, regulatory engagement, and investigator collaboration Partner across functions to define and implement clinical development strategies and plans for multiple programs Serve as the primary medical expert and point of contact for clinical and scientific questions across internal and external stakeholders Represent Olema in interactions with investigators, academic collaborators, thought leaders, and regulatory authorities Maintain strong clinical and scientific acumen through ongoing engagement with the oncology community and key scientific meetings Design and Deliver High-Impact Clinical Studies Provide medical oversight and partner with CROs for Phase 3 programs and ensure alignment with Olema’s values, SOPs, and ethical standards Lead the development and execution of clinical protocols, amendments, investigator brochures, study reports, abstracts, and manuscripts Ensure scientific rigor and data integrity in partnership with cross-functional internal teams (i.e. Clinical Operations, Biostatistics, Safety) and CRO teams Evaluate safety, pharmacology, and efficacy data from ongoing and completed studies to inform program strategy and decision-making Contribute to regulatory submissions and communications Collaborate with preclinical and translational scientists to develop and integrate biomarker strategies Support data generation, publication planning, and external communication of study results Ideal Candidate Profile: Experienced Oncology Physician Leader You are an accomplished clinical development physician who thrives on meaningful, challenging work and is motivated by the opportunity to make a lasting impact on patients’ lives. You combine deep clinical and scientific expertise with strategic vision, collaboration, and a hands-on approach to execution. Knowledge MD required Board certification in Oncology, Hematology/Oncology, or related specialty; significant experience in breast cancer may substitute 5+ years of direct biotech or pharmaceutical experience in clinical development, with leadership in late-phase studies Strong understanding of breast cancer treatment paradigms; experience with ER+/HER2- disease preferred Experience Proven success in designing, leading, and managing late-phase (registrational) studies in oncology; experience as a PI or academic breast cancer expert is also valued Deep understanding of the drug development process and ability to translate strategy into action—meeting milestones, managing budgets, and adapting to change Strong knowledge of GCP, FDA, and EMA/CHMP regulations; familiarity with other global regulatory standards is advantageous Effective leadership in a matrixed environment, influencing without authority and driving cross-functional alignment Exceptional communication skills—able to convey complex clinical data with clarity and purpose to both scientific and non-scientific audiences Demonstrated problem-solving ability with urgency, focus, and creativity Proven record of building collaborative, high-performing teams and partnerships Highly organized, detail-oriented, and adaptable to fast-paced, evolving priorities Attributes Strategic, decisive, and collaborative leader who inspires confidence and trust Strong communicator with credibility among internal teams and external stakeholders Relationship builder who thrives in a dynamic, mission-driven environment Committed to lifelong learning and continuous professional growth The base pay range for this position is expected to be $315,000 - $350,000 annually, however the base pay offered may vary depending on location, market, job related knowledge, skills and capabilities, and experience. The total compensation package for this position also includes equity, bonus, and benefits. #LI-AD1 Important Information >>> We provide equal opportunity to all employees and applicants for employment and believe that great ideas and discoveries come from a mix of expertise, background, and experience. Olema is building a culture where the value of difference is celebrated. We offer a competitive compensation and benefits package, seeking to provide an open, flexible, and friendly work environment to empower employees and provide them with a platform to develop their long-term careers. A Summary of Benefits is available for all applicants. Please note: Olema doesn’t accept agency resumes and is not responsible for any fees related to unsolicited resumes. Thank you. Fraud Alert: We are aware of employment scams where individuals pose as representatives of Olema Oncology and make false use of our company name to defraud job seekers. To protect yourself, please note that Olema’s official email addresses end in @olema.com. Our official corporate website is olema.com; our careers page is olema.com/careers; our LinkedIn page is linkedin.com/company/olema-oncology. Please visit these links for official information from Olema. Communication from any other variant is fraudulent. Olema does not conduct interviews via text message/messaging platforms, will not ask you to download anything as part of your interview, will never request any form of payment, provide upfront payments of any kind, and does not make job offers without an in-person interview.

Responsibilities

Lead registration-enabling studies for palazestrant and ensure scientific rigor and data integrity. Collaborate with cross-functional teams and external stakeholders to advance Olema’s late-stage clinical pipeline.