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Senior Modelling Scientist at Newton Colmore Consulting Ltd

London, London - England, United Kingdom -

Full Time

Start Date

Immediate

Expiry Date

18 Dec, 26

Salary

60000.0

Posted On

19 Sep, 26

Experience

8 year(s) or above

Remote Job

Yes

Telecommute

Yes

Sponsor Visa

Yes

Skills

Industry

Pharmaceutical Manufacturing

Description

PhD or MSc in Pharmaceutical Sciences, Biopharmaceutics, Pharmacokinetics, Pharmacometrics, Chemical Engineering or a related scientific discipline. For MSc candidates, substantial relevant industrial experience in PBPK, PBBM, pharmacometrics, mechanistic modelling or model-informed drug development is required.
Demonstrated expertise in PBPK, PBBM, pharmacometrics, mechanistic modelling, or model-informed drug development.
Strong understanding of oral absorption, dissolution, permeability, biopharmaceutics, and pharmacokinetics.
Experience with PBPK/PBBM modelling software such as Simcyp, GastroPlus, PK-Sim or similar platforms.
Demonstrated ability to apply modelling to solve pharmaceutica

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Responsibilities

Develop, verify, and apply PBBM and PBPK models using platforms such as Simcyp, GastroPlus or equivalent software.
Support the prediction and assessment of oral absorption, food effect, bioavailability, formulation bridging, dissolution and particle size specifications, and virtual bioequivalence.
Perform model calibration, sensitivity analyses, scenario testing, and uncertainty assessments to support project decisions.
Collaborate with laboratory scientists to design and interpret in vitro studies supporting model development and verification.
Support the development of clinically relevant dissolution methods and in vitro-in vivo links where appropriate.