Senior Protein Scientist at Syngenta Group

Bracknell, England, United Kingdom -

Full Time

Start Date

Immediate

Expiry Date

29 Jun, 26

Salary

0.0

Posted On

31 Mar, 26

Experience

5 year(s) or above

Remote Job

Yes

Telecommute

Yes

Sponsor Visa

Skills

Protein Expression, Protein Purification, Troubleshooting, Method Development, Scale-up Processes, E.coli, Pichia, Cell Free, Construct Design, Affinity Chromatography, IEX, HIC, SEC, High-throughput, Automated Liquid Handling, DoE

Industry

Farming

Description

Company Description Syngenta Crop Protection is a leader in agricultural innovation, bringing breakthrough technologies and solutions that enable farmers to grow healthy and nutritious food while taking care of the planet. We offer a leading portfolio of crop protection solutions for plant and soil health, as well as digital solutions that transform the decision-making capabilities of farmers. Our 17,900 employees serve to advance agriculture in more than 90 countries around the world. Syngenta Crop Protection is headquartered in Basel, Switzerland, and is part of the Syngenta Group. Our employees reflect the diversity of our customers, the markets where we operate and the communities which we serve. Regardless of your position, you will have a vital role in safely feeding an ever-increasing population while taking care of our planet. Join us and help shape the future of agriculture. Job Description We have an exciting opportunity for a lab-based Senior Protein Scientist specialising in recombinant protein production. Within this hands-on role you will focus on protein expression, purification, and characterization, with emphasis on troubleshooting complex protein production challenges, while being responsible for developing and optimizing protein production workflows, including method development and scale-up processes. Key responsibilities will include: Executing and troubleshooting protein expression and purification projects, while developing robust and scalable processes. Optimizing protein expression conditions across various systems (E.coli, Pichia, cell free) to maximize yield and quality. Designing and implementing purification strategies for challenging proteins. Performing protein quantification and characterization using various analytical and biophysical techniques. Developing and validating high-throughput protein production workflows using automated systems using established SOPs with further optimisation where necessary. Maintaining accurate experimental records with ability to analyse complex datasets. Communication project results. Ensuring compliance with company HSE policies. Qualifications What we are looking for PhD in Biology, Biochemistry, Biomedical Sciences, or related fields or BSc/MSc with extensive relevant laboratory experience. Strong hands-on experience in construct design, protein expression and purification, with demonstrated troubleshooting abilities. Expertise in protein purification techniques (affinity, IEX, HIC, SEC). Practical knowledge of protein characterization methods. Experience with various expression systems (E. coli, Pichia, cell free). Desirable experience Experience with difficult-to-express proteins with construct design knowledge. Knowledge of high-throughput protein production workflows with interest in automating protein expression pipelines. Experience with automated liquid handling systems (e.g., Tecan) would be a plus. Understanding of design of Experiments (DoE) with the mindset of process optimisation. Knowledge of analytical techniques (SEC-MALS, DSF, CD, DLS). Additional Information Our site Jealott's Hill International Research Centre UK is situated in pleasant semi-rural surroundings between Bracknell and Maidenhead and is the place of work for approximately 800 Syngenta scientists and support staff. Jealott’s Hill is one of the main global research and development sites and key activities include research into discovery of new active ingredients, new formulation technologies, product safety and technical support of our product range. What we offer Extensive benefits package including a generous pension scheme, bonus scheme, private medical & life insurance. Up to 31.5 days annual holiday. Campus environment. We offer a position which contributes to valuable and impactful work in a stimulating and international environment. The chance to work with and learn from highly qualified and experienced employees. A vibrant growth and learning culture and wide range of training options. Syngenta has been ranked as a top 5 employer and number 1 in agriculture by Science Journal. Syngenta is an Equal Opportunity Employer and does not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Learn more about our D&I initiatives here: https://www.syngenta.com/careers/working-syngenta/diversity-and-inclusion Jealott’s Hill has Disability Confident certification. We are committed to making all stages of our recruitment process accessible to all candidates and our Jealott’s Hill site are a Disability Confident Level 2 Employer. Please let us know if you need any assistance or reasonable adjustments throughout your application and we will do everything we can to support you.

Responsibilities

This hands-on role focuses on protein expression, purification, and characterization, emphasizing troubleshooting complex production challenges and developing/optimizing workflows, including method development and scale-up. Key tasks involve executing and troubleshooting expression/purification projects, optimizing expression conditions across various systems, and designing purification strategies for challenging proteins.