Senior Research Associate, CryoEM at GENERATE BIOMEDICINES INC

Andover, Massachusetts, United States -

Full Time

Start Date

Immediate

Expiry Date

10 Jan, 26

Salary

108000.0

Posted On

12 Oct, 25

Experience

2 year(s) or above

Remote Job

Yes

Telecommute

Yes

Sponsor Visa

Skills

Protein Purification, CryoEM, Data Analysis, Troubleshooting, Collaboration, Protein Expression, Analytical Techniques, Process Optimization

Industry

Biotechnology Research

Description

About Generate:Biomedicines Generate:Biomedicines is a new kind of therapeutics company – existing at the intersection of machine learning, biological engineering, and medicine – pioneering Generative Biology™ to create breakthrough medicines where novel therapeutics are computationally generated, instead of being discovered. The Company has built a machine learning-powered biomedicines platform with the potential to generate new drugs across a wide range of biologic modalities. This platform represents a potentially fundamental shift in what is possible in the field of biotherapeutic development. We pursue this audacious vision because we believe in the unique and revolutionary power of generative biology to radically transform the lives of billions, with an outsized opportunity for patients in need. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us! Generate:Biomedicines was founded in 2018 by Flagship Pioneering and has received nearly $700 million in funding, providing the resources to rapidly scale the organization. The Company has offices in Somerville and Andover, Massachusetts with 300+ employees. Location: Andover, MA (On-site, Full-Time) Generate Biomedicines is seeking a Senior Research Associate to join our CryoEM Group in generating large-scale protein structural datasets. This role offers the opportunity to work at the intersection of protein biochemistry and cutting-edge structural biology, contributing to our mission of accelerating drug discovery through advanced imaging technologies. How You Will Contribute: Drive the advancement of experiments and technologies by performing protein purification, complexation, vitrification, and clipping, ensuring high-quality sample preparation for CryoEM. Operate CryoEM microscopes and execute automated data collection workflows with minimal guidance. Interpret and troubleshoot experimental data, contributing to planning and prioritization of concurrent CryoEM experiments. Apply and refine data analysis methods; determine reliability of results and communicate findings in presentations or team meetings. Collaborate with multidisciplinary teams to support high-throughput protein structure determination. Document experimental data and report findings in internal databases. Contribute to process optimization and implementation of new protocols. Qualifications: Recombinant protein expression in E. coli and mammalian cell lines, protein purification (ÄKTA-based), and associated analytical techniques (aSEC, DSF, SDS-PAGE). Demonstrated ability to work independently with minimal guidance while contributing to a collaborative research environment. Excellent troubleshooting and attention to detail. Preferred Additional Skills Prior exposure to CryoEM workflows or microscope operation (e.g., SerialEM, Vitrobot, GP2). Hands-on experience with liquid handlers (Tecan, Hamilton). Experience running binding assays (e.g., Octet or Gator Bio). Experience Bachelors Degree with 4+ or Masters Degree with 2+ years of experience. Additional Information On-site position at our Andover, MA CryoEM lab. Generate:Biomedicines is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. Recruitment & Staffing Agencies: Generate:Biomedicines does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Generate:Biomedicines or its employees is strictly prohibited unless contacted directly by the Company’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Generate:Biomedicines and the Company will not owe any referral or other fees with respect thereto. #LI-AE1 Compensation: The base salary range provided reflects our current estimate of what we anticipate paying for this position. Your actual base salary will be based on several factors, including job-related skills, experience, internal equity, relevant education or training, and market dynamics. In addition, you will be eligible for an annual bonus, equity compensation, and a competitive benefits package. Per Year Salary Range $83,000—$108,000 USD

Responsibilities

The Senior Research Associate will drive the advancement of experiments and technologies by performing protein purification and operating CryoEM microscopes. They will also interpret experimental data and collaborate with multidisciplinary teams to support protein structure determination.