Senior Research Associate at Oregon Health & Science University

Portland, Oregon, United States -

Full Time

Start Date

Immediate

Expiry Date

07 Jul, 26

Salary

97968.0

Posted On

08 Apr, 26

Experience

5 year(s) or above

Remote Job

Yes

Telecommute

Yes

Sponsor Visa

Skills

Organoid culture, Sterile technique, qPCR, Western blotting, Immunostaining, Advanced imaging, Proteomics, Transcriptomics, Bioassays, Molecular biology, Biochemistry, Cell culture, Microscopy, Bioinformatics, Data analysis, Laboratory management

Industry

Higher Education

Description

Department Overview The laboratory of Brian Scottoline at the Pape Family Pediatric Research Institute, is locaed in the Department of Pediatrics. In conjunction with the adjacent and collaborating laboratory of Sarah Andres we investigate the roles of human milk beyond nutrition, specifically, the impacts of human milk on intestinal epithelial cell biology, and the mechanisms of those interactions. We are particularly interested in how human milk reduces the risk for the devastating neonatal intestinal inflammatory disease, necrotizing enterocolitis. We are at the forefront of human milk research, using rare patient digrsted milk samples and, patient-derived intestinal organoids to investigate these questions. Function/Duties of Position We are looking for a dynamic, organized, self-starter with a PhD or Masters degree with experience to help us make new discoveries. A strong candidate with a BS degree in Biology or Chemsitry with extensive researchexperience may also be considered. The Senior Research Associate is responsible for executing, and overseeing complex organoid experiments and developing functional assays to delineate mechanisms of human milk action on intestinal development and maturation. This involves generating neonatal patient-derived intestinal organoids (enteroids) from surgical tissue samples. Cultivating enteroids requires keen attention to detail and impecable sterile technique. The Senior Research Associate is also responsible the handling and purification of milk samples for exploring the physiology of milk interactions with intestinal epithelium, and for running various downstream cellular and molecular analyses including, qPCR, western blotting, immunostaining, advanced imaging, proteomics, and transcriptomics. The position also requires the ability to develop new or optimize existing bioassays. The ability to manage multiple co-occuring experiments is essential. In addition to primary project responsibilitoes, this position may assist lab team members with experiments involving neonatal mouse models of the neonatal intestinal inflammatory disease necrotizing enterocolitis, and support for collaborating labs with visting members. Required Qualifications PhD in relevant field AND 1 year of relevant experience OR Master's Degree in relevant field AND 5 years of relevant experience OR Bachelor's Degree in relevant field AND 9 years of relevant experience. Working as part of a team Working independently Working in dynamic, stimulating environment Dynamic Organized Self-starter Willing to learn new skills Flexible Good time management Ability to multitask Strong oral and written communication skills Strong problem solving skills Detail oriented Inquisitive Persistent Preferred Qualifications Degree in life sciences Biomedical research laboratory experience Molecular biology Biochemistry Cell culture techniques Sterile technique Bioinformatic experience Microscopy Immunostaining Additional Details ***Upload cover letter and resume. Please be sure to include months and years (MM/YYYY format) to the resume for jobs/work experience.*** OHSU Employees be sure to apply using your OHSU email. Why apply to OHSU? We are Oregon's only public academic health center. In addition to caring for patients, we lead groundbreaking research. We also train the next generation of health care professionals. As Portland's largest employer, we give you opportunities to learn and advance in a system of hospitals and clinics across Oregon and Southwest Washington. All are welcome. OHSU welcomes people of all ages, ethnicities, genders, national origins, religions and sexual orientations. We are striving to build an anti-racist, multicultural institution and encourage people with diverse backgrounds to apply. To request reasonable accommodation, contact askhr@ohsu.edu

Responsibilities

The Senior Research Associate is responsible for executing complex organoid experiments and developing functional assays to study the effects of human milk on intestinal development. They will also manage laboratory tasks, including sample purification and various molecular and cellular analyses.