Senior Scientist at AstraZeneca

Cambridge, Massachusetts, United States -

Full Time

Start Date

Immediate

Expiry Date

08 Aug, 26

Salary

174426.0

Posted On

10 May, 26

Experience

5 year(s) or above

Remote Job

Yes

Telecommute

Yes

Sponsor Visa

Skills

LC-MS, Protein Characterization, Peptide Mapping, Mass Spectrometry, Chromatography, Data Analysis, Statistical Methods, AI Tools, Assay Development, Biophysical Characterization, Protein Metrics Suite, BioPharma Finder, PEAKS, Python, MATLAB, PyMOL

Industry

Pharmaceutical Manufacturing

Description

Job Title: Senior Scientist – Analytics & Mass Spec Location: Cambridge, MA At AstraZeneca, we put patients first and strive to meet unmet patient needs worldwide. Working here means being ambitious, thinking big, and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person. About the Site Our Kendall Square site in Cambridge, MA is part of AstraZeneca’s vibrant R&D community and brings together world-class scientific talent, innovative technologies, and collaborative ways of working to discover and develop life-changing medicines for patients around the world. Located in one of the world’s leading biotechnology hubs, the site is designed to foster cross-functional teamwork, scientific innovation, and operational excellence. Summary of the Group Biologics Engineering (BE) is a large global organization with teams in Cambridge, MA, Gaithersburg, MD and Cambridge, UK, responsible for the discovery and optimization of next-generation biologics to create biological drug candidates across key therapeutic areas. Main Duties & Responsibilities We are seeking a highly qualified and motivated Senior Scientist to join the Analytics & Mass Spec Group within the multidisciplinary Protein Analytics & Developability team. The successful candidate will play a key role in advancing our capabilities in high throughput intact protein analysis, peptide mapping for post-translational modification, and analytical and developability assessment. Reporting to the Associate Director of the Analytics & Mass Spec Group, the Senior Scientist will work closely with a multidisciplinary team to support various stages of our pipeline projects and give to the enhancement of our technology platforms through mass spectrometry and analytical techniques. Perform and optimize high-throughput (HT) intact protein analysis, including data acquisition, data processing, and reporting for discovery-stage biologics such as antibodies, multispecifics, and various protein reagents. Develop and apply advanced analytical tools, focusing on mass spectrometry and chromatography-based techniques, to characterize discovery-stage biotherapeutics, facilitating critical decision-making. Design and implement peptide mapping assays for protein characterization to support the developability assessment of pipeline projects. Conduct analytical methods to deeply characterize the biophysical and biochemical properties of discovery-stage biologics. Collaborate with the Protein Analytics and Developability team to refine HT assay workflows, ensuring accuracy and reliability in data collection and interpretation. Analyze and interpret complex datasets, providing insights to drive decision-making in pipeline projects. Stay at the forefront of technological advancements in mass spectrometry and other analytical technologies, integrating innovative solutions to enhance current workflows. Participate in cross-functional project teams, giving technical expertise to inform project strategies and directions. Draft technical reports and supply to scientific publications, patents, and regulatory submissions as necessary. Mentor junior scientists in experimental design and data analysis to cultivate a collaborative and productive research environment. Required Skills: Confirmed expertise in LC-MS (ThermoFisher Orbitrap, Agilent QTOF) and software platforms, including Protein Metrics Suite, BioPharma Finder and PEAKS, for intact mass deconvolution, peptide mapping analysis, post-translational modifications (PTMs), characterization of charge variants, and disulfide mapping. Hands-on experience with a wide variety of analytical methods for protein characterization, including but not limited to LC-MS, HIC, SEC, cIEF, IEX, CE-SDS, DLS, DSC, DSF and ELISA. Experience in assay troubleshooting and optimization, with a strong understanding of assay development and execution. Proficiency in data analysis and statistical methods for interpreting complex biological data. Strong collaborative skills and ability to work effectively within multidisciplinary teams. Excellent communication and presentation skills to convey technical information clearly and succinctly. AI-fluent, with the ability to use AI tools effectively to support data analysis, interpretation, workflow efficiency, and scientific communication. Desired Skills : Hands-on experience with additional high-throughput, plate-based protein analytical and biophysical techniques, instrumentation, and automation platforms. Programming and software skills, including Python, MATLAB, PyMOL and Maestro. Hands-on experience with AI/ML methods (e.g., supervised learning, statistical modeling, and automation) to support advanced analytical workflows and data-driven decision-making. Experience working in a global, cross-site research environment. Minimum Education & Experience Requirements BS with 5+ years of relevant experience MS with 3+ years of relevant experience PhD with relevant experience Relevant fields include: Scientific disciplines: biochemistry, molecular biology, or related fields Computational disciplines: computer science or related fields (with the necessary mass spectrometry background) The annual base pay (or hourly rate of compensation) for this position ranges from $116,284.00 - $174,426.00. Our positions offer eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans. Date Posted 09-May-2026 Closing Date 17-May-2026 Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form. AstraZeneca is a global, science-led, patient-focused biopharmaceutical company. We focus on discovering, developing and commercialising prescription medicines for some of the world’s most serious diseases. But we are more than one of the world’s leading pharmaceutical companies. At AstraZeneca, we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science, challenge convention and unleash your entrepreneurial spirit. To embrace differences and take bold actions to drive the change needed to meet global healthcare and sustainability challenges. There is no better place to make a difference in medicine, patients, and society. An inclusive culture where you will connect different thinking to generate new and valuable opportunities. Where you will find a commitment to lifelong learning, growth and development for all. Our Inclusion & Diversity (I&D) mission is to create an inclusive and equitable environment where people belong, using the power of our diversity to push the boundaries of science to deliver life-changing medicines to patients. Inclusion and diversity are fundamental to the success of our company, because innovation requires breakthrough ideas that only come from a diverse workforce empowered to challenge conventional thinking. We’re curious about science and the advancement of knowledge. We find creative ways to approach new challenges. We’re driven to make the right choices and be accountable for our actions. As an organisation centred around what makes us human, we put a big focus on people. Across our business, we want colleagues to wake up excited about their day at the office, in the field, or in the lab. Along with our purpose to bring life-changing medicines to people across the globe, we have a promise to you: to help you realise the full breadth of your potential. Here, you’ll do work that has the potential to change your life and improve countless others. And, together with your team, you’ll shape a culture that unites and inspires us every day. This is your life at AstraZeneca.

Responsibilities

The Senior Scientist will lead high-throughput intact protein analysis and peptide mapping to support the developability assessment of discovery-stage biologics. They will collaborate with multidisciplinary teams to optimize analytical workflows and integrate innovative mass spectrometry solutions.