Senior Scientist, Discovery & Translational Development at Solid Biosciences

Boston, Massachusetts, United States -

Full Time

Start Date

Immediate

Expiry Date

05 May, 26

Salary

180000.0

Posted On

04 Feb, 26

Experience

5 year(s) or above

Remote Job

Yes

Telecommute

Yes

Sponsor Visa

Skills

Neuromuscular Biology, Gene Therapy, AAV Gene Therapy, Translational Research, Preclinical Studies, Data Analysis, Molecular Biology, Cell Biology, Biomarker Strategies, Statistical Analysis, Collaboration, Scientific Communication, Experimental Design, Mentoring, Critical Thinking, Regulatory Support

Industry

Biotechnology Research

Description

Senior Scientist, Discovery and Translational Development – Solid Biosciences Charlestown, MA Solid Biosciences is a precision genetic medicine company focused on advancing a portfolio of gene therapy candidates targeting rare neuromuscular and cardiac diseases, including Duchenne muscular dystrophy (Duchenne), Friedreich’s ataxia (FA), catecholaminergic polymorphic ventricular tachycardia (CPVT), TNNT2-mediated dilated cardiomyopathy, BAG3-mediated dilated cardiomyopathy, and additional fatal, genetic cardiac diseases. We are advancing a diverse pipeline and delivery platform in the pursuit of uniting experts in science, technology, disease management, and care. Patient-focused and founded by those directly impacted by Duchenne, Solid’s mission is to improve the daily lives of patients living with devastating rare diseases. The Senior Scientist will be a key contributor within the Discovery & Translational Development (DTD) group at Solid Biosciences, supporting the advancement of AAV-based gene therapy programs for neuromuscular diseases, with a primary focus on Duchenne Muscular Dystrophy (DMD). This role sits at the interface of discovery, translational science, and early development. The Senior Scientist will be responsible for generating high-quality preclinical and translational data to inform program strategy, support IND-enabling activities, and enable confident clinical interpretation. Success in this role requires strong neuromuscular biology expertise, hands-on experience with AAV gene therapy, and the ability to operate effectively within a cross-functional, industry-driven environment. This role will report to the Head of Discovery & Translational Development and will be based in Solid’s Corporate Headquarters located in Hood Park in Charlestown, MA and is a primarily onsite position. Key Position Responsibilities * Preclinical & Translational Research Execution * Design, execute, and interpret studies supporting DTD neuromuscular gene therapy programs, including DMD. * Generate mechanistic and translational data evaluating transgene expression, biodistribution, durability, and functional impact in relevant disease models. * Develop and implement biomarker strategies aligned with DTD objectives, linking preclinical readouts to clinical endpoints (e.g., molecular, histological, biochemical, and functional measures). * Ensure scientific rigor, reproducibility, and appropriate statistical analysis across all studies. * Program & IND-Enabling Support * Contribute to IND-enabling data packages, including study design, data interpretation, and preparation of technical reports and regulatory-supporting documentation. * Partner closely with Clinical, Bioanalytics, Regulatory, CMC, and Program Management to ensure translational alignment and operational execution. * Support development and refinement of translational hypotheses, target product profiles (TPPs), and go/no-go decision criteria. * Cross-Functional & External Collaboration * Actively participate in DTD program teams and scientific governance forums. * Communicate complex datasets clearly to internal stakeholders, including DTD leadership and executive audiences. * Manage or support external CROs and academic collaborators to ensure delivery of high-quality data on agreed timelines. * Scientific Leadership & Culture * Embody DTD values of scientific rigor, accountability, and translational relevance. * Contribute to the evolution of DTD experimental platforms, biomarker frameworks, and best practices. * Mentor research associates or junior scientists as appropriate, fostering scientific growth and data integrity. Experience Requirements * PhD in Muscle Biology, Neuroscience, Molecular Biology, Cell Biology, Genetics, Pharmacology, or a related life sciences discipline. * Postdoctoral training in neuromuscular disease or gene therapy is preferred. * 5–8+ years of relevant experience, with a strong preference for biotechnology or pharmaceutical industry experience. * Direct experience supporting neuromuscular disease programs, ideally DMD. * Hands-on experience with AAV gene therapy platforms, including in vivo studies. * Experience contributing to translational research and IND-supporting activities is highly desirable. * Preclinical neuromuscular disease models (e.g., mdx and related models). * Molecular and cellular assays relevant to gene therapy (e.g., qPCR, immunofluorescence, Western blot, ELISA). * Histological and imaging-based evaluation of muscle pathology and transgene expression. * Data analysis, visualization, and interpretation using standard industry tools. Key Position Attributes * Strong grounding in neuromuscular disease biology, with deep familiarity in DMD pathophysiology. * Demonstrated expertise in AAV-based gene therapy, including capsid biology, transgene expression, and tissue tropism. * Translational mindset with the ability to connect preclinical findings to clinical interpretation. * High level of scientific rigor, critical thinking, and experimental design capability. * Strong written and verbal communication skills, including experience presenting data to multidisciplinary teams. * Ability to manage multiple workstreams in a fast-paced biotechnology environment. Compensation The base compensation range for this role is: $145,000 - $180,000 Base salary offered is determined through an internal analysis utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity. Regular employees are eligible to receive both short-term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward individual performance and align incentives to Solid’s long term company performance. Benefits and Solid Advantages At Solid Biosciences we offer a highly competitive total rewards and benefits package, intended to support all aspects of our employees’ lives and well-being. Additionally, for those employees working onsite at our Hood Park Headquarters, we offer a variety of onsite resources to support those working in our offices. * Competitive Health and Dental programs with flexible plan offerings, including FSA and HSA programs * 401(k) program participation with competitive company matched contributions * Eligibility to participate in Solid’s Employee Stock Purchase Plan * Mobile phone subsidy for eligible employees * Tuition Reimbursement * Vision Coverage * Life Insurance * Voluntary Pet Insurance * Employee Discount Program on Travel, Entertainment, and Services * Employee Assistance Programs * Daily Subsidized Lunch Delivery (onsite @ Hood Park) * Free Onsite Full-Service Gym (onsite @ Hood Park) * Employee Parking (onsite @ Hood Park) * 12 Observed Holidays and a winter shut down * 15-day PTO Policy and a 40-hour rollover YoY * 40-hour Sick Policy * 8 Hour Floating Holiday

Responsibilities

The Senior Scientist will design, execute, and interpret studies supporting neuromuscular gene therapy programs, focusing on Duchenne Muscular Dystrophy. They will generate preclinical and translational data to inform program strategy and support IND-enabling activities.