JOB DESCRIPTION

You will be one of the lead senior scientists who oversees processes relating to VLP design, expression and purification. Having cross-functional experience is essential, as is having a team-player mentality. The precise type of activity you will be assigned will change according to current demands, but will include:
· The optimisation of culturing conditions for VLP expression of test clones and strains in a range of expression systems (bacteria, insect, mammalian)
· The creation of VLP purification methodologies using IMAC, IEC, SEC, IEX, HIC chromatography
· The performance of buffer optimisation methods using TFF
· The assessment of formulation and stability of samples produced in-house
· The supervision and training of other members of the team
· Working independently, reading literature and communicating emerging technology developments
· Ensuring accurate record keeping, and compiling detailed ELN entries for all experiments
· Drafting reports, preparing presentations, and communicating work to other members of the group
· Working under the pressure of milestone–driven timelines

EXPERIENCE AND QUALIFICATIONS

• Ph.D plus 5 years industry experience in protein production, or equivalent experience

KEY REQUIREMENTS

• Previous experience in the optimisation of bacteria, insect, and mammalian cultures for protein production efforts (essential)
• Previous experience in AKTA chromatography method development (essential)
• An understanding of VLP expression and purification methods (desirable)
• Understanding of process development methods for vaccine production (desirable)
• Previous management of junior team members in a protein production environment (desirable)
• Previous experience in an industry setting (desirable)

Please refer the Job description for details