EDUCATION/EXPERIENCE/KNOWLEDGE & SKILLS:

• Ph.D. in analytical chemistry or related discipline with zero or more years of chromatography experience related to drug discovery; or,
• MS in analytical chemistry or related discipline and a minimum of five years of chromatography experience related to drug discovery; or,
• BS in analytical chemistry or related discipline and a minimum of seven years of chromatography experience related to drug discovery; or,
• Equivalent combination of education and experience.

Experience (desired):

• Experience using LCMS, UPLC and SFC in drug discovery setting
• Experience with purification and characterization of small molecule compounds
• Experience with automation for liquid handling processes

Knowledge/Skills:

• Knowledge of automatic liquid handler/Robotics and related data processing software
• Strong knowledge of small molecule separation by modern chromatographic techniques such as Reverse Phase LC/UPLC, LCMS and SFC.
• Strong knowledge of LC, LCMS and SFC instrumentation
• Good interpersonal skills, flexibility and works well within a team environment
• Excellent written and verbal communication skills

DISCLAIMER

The preceding job description has been designed to indicate the general nature and level of work performed by employees within this classification. It is not designed to contain or be interpreted as a comprehensive inventory of all duties, responsibilities and qualifications required of employees assigned to the job.
We are an Equal Opportunity Employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity, status as a veteran, and basis of disability or any other federal, state or local protected class

SUMMARY/JOB PURPOSE:

The successful candidate will be responsible for day-to-day small molecule separation, separation and characterization activities using industry-leading chromatography tools for research and development projects. The successful candidate will also be responsible for managing external vendors and service providers for laboratory instrument maintenance, troubleshooting and technical/process development to optimize analytical workflow efficiency and throughput.

ESSENTIAL DUTIES AND RESPONSIBILITIES:

• Perform high throughput compound library purification using LCMS detection and automation software.
• Perform separation, purification, analysis and scale up purification of small molecule compounds from medicinal chemistry synthesis including chiral separation.
• Use chromatographic methods including HPLC/UPLC, LCMS and SFC to separate compounds with complex matrices (problem solving).
• Ability to use automated liquid handler robots to perform sample preparation pre and post purification.
• Perform data analysis and prepare analysis report under supervision.
• Participate in group, project team and departmental research meetings.
• Maintain laboratory notebooks in accordance with company policies and practices.
• Comply with safe laboratory practices and EH&S guidelines.