Senior Scientist, I, siRNA in vitro Biology

Cambridge, MA

• Function: Research & Development
• Job Type: Full-time

Job ID: R00133119
Company Description
AbbVie’s mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio.
Job Description
AbbVie is looking for a Senior Scientist I to join our siRNA group within the Biotherapeutics and Genetic Medicine (BGM) department. This role will involve designing and executing innovative experimental approaches to address key scientific challenges related to oligonucleotide therapeutics. The successful candidate will drive scientific innovation, identify new methods and techniques, and collaborate across functions to support the development of novel RNA-based therapies.

WHY ABBVIE?

AbbVie is a global biopharmaceutical company committed to bringing innovative medicines to patients in need. We offer a collaborative work environment, opportunities for professional growth, and the ability to make an impact on the future of healthcare. Join us and be part of a team that is transforming the landscape of genetic medicine.
Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
• This job is eligible to participate in our short-term incentive programs.

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company’s sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.
AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.
US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html
US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:
https://www.abbvie.com/join-us/reasonable-accommodations.htm

Qualifications

• BS, MS, or PhD in Cell Biology, Molecular Biology, Biochemistry, or related field with typically 10+ (BS), 8+ (MS), or 0+ (PhD) years of relevant experience.
• Extensive hands-on experience in the design, development, optimization, and validation of in vitro assays to support oligonucleotide and/or RNA-based therapeutic development is required.
• Strong background in cell and molecular biology techniques including mammalian cell culture, mRNA isolation and quantitation (qPCR), ELISA, Western blot, and nucleic acid sequencing (NGS/Sanger).
• Proven ability to troubleshoot and refine assays to enhance sensitivity, reproducibility, and throughput.
• Demonstrated track record of independently developing fit-for-purpose assays that directly inform lead optimization and mechanism-of-action studies.
• Familiarity with CNS disease models and DNA/RNA editing tools is highly desired.
• Bioinformatics and/or programming experience for data analysis is a strong asset.
• Exceptional scientific rigor, analytical thinking, and problem-solving skills, with the ability to synthesize data into actionable insights.
• Highly self-motivated with the ability to thrive in a fast-paced, collaborative team environment.
• Strong written and verbal communication skills, including experience contributing to technical reports, publications, or regulatory documentation

• Lead research efforts within a cross-functional team to advance siRNA platform development for therapeutic applications.
• Resolve key project hurdles and assumptions utilizing available information and technical expertise
• Work autonomously to perform laboratory research or develop methods with minimal supervision, consistently delivering high-quality results.
• Demonstrate expertise in a wide range of relevant technologies and methodologies.
• Conceive and execute novel scientific research that achieves project goals
• Maintain high productivity in the laboratory, ensuring efficiency in experiment execution.
• Analyze and interpret multidisciplinary data, generating conclusions that drive future experimental directions.
• Contribute as a primary author to publications, presentations and/or as a primary inventor of patents.

Qualifications

• BS, MS, or PhD in Cell Biology, Molecular Biology, Biochemistry, or related field with typically 10+ (BS), 8+ (MS), or 0+ (PhD) years of relevant experience.
• Extensive hands-on experience in the design, development, optimization, and validation of in vitro assays to support oligonucleotide and/or RNA-based therapeutic development is required.
• Strong background in cell and molecular biology techniques including mammalian cell culture, mRNA isolation and quantitation (qPCR), ELISA, Western blot, and nucleic acid sequencing (NGS/Sanger).
• Proven ability to troubleshoot and refine assays to enhance sensitivity, reproducibility, and throughput.
• Demonstrated track record of independently developing fit-for-purpose assays that directly inform lead optimization and mechanism-of-action studies.
• Familiarity with CNS disease models and DNA/RNA editing tools is highly desired.
• Bioinformatics and/or programming experience for data analysis is a strong asset.
• Exceptional scientific rigor, analytical thinking, and problem-solving skills, with the ability to synthesize data into actionable insights.
• Highly self-motivated with the ability to thrive in a fast-paced, collaborative team environment.
• Strong written and verbal communication skills, including experience contributing to technical reports, publications, or regulatory documentation.

If you are passionate about advancing RNA-based therapeutics and have a track record of success in cell and molecular biology, we encourage you to apply! Please submit your resume outlining your relevant experience and why you would be a great fit for this position.