Senior Scientist II, Large Scale Biotherapeutic Purification

at  Generate Biomedicines

ABOUT GENERATE:BIOMEDICINES

Generate:Biomedicines is a new kind of therapeutics company – existing at the intersection of machine learning, biological engineering, and medicine – pioneering Generative Biology™ to create breakthrough medicines where novel therapeutics are computationally generated, instead of being discovered. The Company has built a machine learning-powered biomedicines platform with the potential to generate new drugs across a wide range of biologic modalities. This platform represents a potentially fundamental shift in what is possible in the field of biotherapeutic development.
We pursue this audacious vision because we believe in the unique and revolutionary power of generative biology to radically transform the lives of billions, with an outsized opportunity for patients in need. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us!
Generate:Biomedicines was founded in 2018 by Flagship Pioneering and has received nearly $700 million in funding, providing the resources to rapidly scale the organization. The Company has offices in Somerville and Andover, Massachusetts with over 300 employees.

Generate:Biomedicines is seeking an experienced, highly motivated, and innovative Senior Scientist II of Biotherapeutics Purification to help manage production and characterization of lead drug candidates across our of our therapeutic pipeline. They will manage and mentor a team of purification scientists across 2 sites(Somerville and Andover, MA) that is responsible for performing protein purification and characterization at various scales across a range of different protein modalities stemming from upstream transient, bacterial and stable cell systems. A variety of capture, polishing and analytics will be used to deliver high quality protein for a variety of uses.
Understanding the importance of how to develop production workflows and appropriate QC for in-vivo grade products is essential to the role as downstream uses include immunogenicity assays, in-vivo PK, efficacy and toxicology studies. Manufacturability risk assessment is essential to the selection process of lead molecules and is a critical part of the role. The successful candidate will help bridge the transfer of lead molecules from R&D to our internal Tech Ops team for pre-clinical manufacturability.
They will guide the development of innovative experiments and technologies by providing direction to the lab or project team to execute complex experiments based on expertise and understanding of program direction and goals; contributing to the development and application of complex and emerging experimental methods to projects or programs within area of expertise; and developing and executing pioneering experiments and approaches to progress programs.
In addition to the core production responsibilities, the ideal candidate will drive scientific strategy within the company by contributing to the development and refinement of program and team goals and executing awareness of emerging trends and scientific advancements; monitoring team members’ scientific understanding and identifying opportunities for professional growth; providing regular input on budget considerations for programs and projects; using project and program timelines to develop achievable team goals; and proactively identifying challenges or issues, developing solutions, and providing recommendations for resolution with the lab or project. Fluid cross functional communication is critical to program success as our production team feeds into several downstream groups to help evaluate lead assets.