Start Date
Immediate
Expiry Date
08 Oct, 25
Salary
0.0
Posted On
09 Jul, 25
Experience
5 year(s) or above
Remote Job
Yes
Telecommute
Yes
Sponsor Visa
No
Skills
Cell Culture, Flow Cytometry, Project Teams, Discovery Process, Cancer Treatment, Mouse Models, Pharmacokinetics, Adcs, Molecular Biology, Pharmacology, Immunoblotting, Patient Outcomes, Oncology, Cancer, Collaborative Environment, Pharmacodynamics, Drug Discovery
Industry
Information Technology/IT
SENIOR SCIENTIST, IN VIVO PHARMACOLOGY, ONCOLOGY TARGETED DISCOVERY
Are you passionate about oncology research and development? Do you want to contribute to life-changing medicines by following the science? Join AstraZeneca as a Senior Scientist in our Oncology Targeted Discovery group in Waltham, Massachusetts. We are looking for a motivated and independent scientist with a proven track record in cancer pharmacology. In this role, you will be instrumental in delivering in vivo pharmacology support, establishing mouse models, and providing critical datasets that impact our drug discovery pipeline.
ACCOUNTABILITIES:
In this laboratory-based position, you will design, execute, and interpret in vivo and ex vivo experiments to evaluate the activity and mechanisms of action of oncology drug candidates. Your research will provide mechanistic insights and efficacy data essential for developing novel therapeutics. Collaborate with cross-functional teams and project leaders to ensure timely delivery and communication of program data. Support scientific publication objectives and stay updated on advances in tumor biology, pharmacology, and cancer modeling.
ESSENTIAL SKILLS/EXPERIENCE:
Significant hands-on experience developing and working with advanced in vivo oncology models, including subcutaneous xenograft, patient-derived xenograft (PDX), syngeneic, disseminated, and PBMC/HSC humanized mouse models.
Direct experience conducting in vivo pharmacology studies using mouse tumor models - including dose-finding, tolerability, pharmacokinetics/pharmacodynamics (PK/PD), and efficacy studies - is essential.
Adept at various routes of dosing administration, such as intravenous (IV), intraperitoneal (IP), and oral gavage (PO).
DESIRABLE SKILLS/EXPERIENCE:
Please refer the Job description for details