OVERVIEW:

A cutting-edge biotech startup is seeking a Mass Spectrometry Scientist to lead analytical efforts across a diverse pipeline of therapeutics. This is a high-impact role for someone passionate about applying advanced analytical techniques to solve complex challenges in therapeutic development.

QUALIFICATIONS:

• M.S. or Ph.D. in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or related field
• 2-5 years of experience in mass spectrometry, preferably in biologics, ADCs, or oligonucleotides
• Hands-on experience with LC-MS/MS, intact protein analysis, peptide mapping, and PK quantification
• Familiarity with conjugation chemistry and CRO management
• Strong data analysis skills using tools like Xcalibur, MassLynx, Skyline, or BioPharma Finder

PREFERRED EXPERIENCE:

• Oligonucleotide/peptide mass spec in biological matrices
• Bioconjugation, protein engineering, or organic synthesis
• Early-stage CMC analytical development and regulatory awareness
• Comfort working in a startup environment with evolving infrastructure

• Perform top-down proteomics for intact mass confirmation and drug-to-antibody ratio (DAR) assessments
• Conduct bottom-up peptide mapping in collaboration with chemists and protein engineers
• Analyze in vivo plasma and tissue samples via LC-MS/MS for PK quantification
• Develop and standardize data processing and reporting pipelines
• Serve as a technical liaison with external CROs and instrumentation partners
• Contribute to the build-out of internal mass spec capabilities, including equipment selection and SOP development
• Collaborate cross-functionally with chemistry, biology, and CMC teams