Senior Scientist, QSP Modeling at Simulations Plus

, , United States -

Full Time

Start Date

Immediate

Expiry Date

05 May, 26

Salary

0.0

Posted On

04 Feb, 26

Experience

10 year(s) or above

Remote Job

Yes

Telecommute

Yes

Sponsor Visa

Skills

QSP Modeling, Pharmacology, Biology, Biochemistry, Immunology, Toxicology, MATLAB, Python, R, PK Modeling, PKPD Modeling, Systems Pharmacology, Critical Thinking, Problem Solving, Communication, Organizational Skills

Industry

Software Development

Description

Simulations Plus stands as a premier provider in the biopharma sector, offering advanced software and consulting services that enhance drug discovery, development, research, clinical trial operations, regulatory submissions, and commercialization. Our comprehensive biosimulation solutions integrate artificial intelligence/machine learning, physiologically based pharmacokinetics, physiologically based biopharmaceutics, quantitative systems pharmacology/toxicology, and population PK/PD modeling approaches. We also deliver simulation-enabled performance and intelligence solutions alongside medical communications support for clinical and commercial drug development. Our cutting-edge technology is licensed and utilized by leading pharmaceutical, biotechnology, and regulatory agencies worldwide. Leadership truly cares about maintaining a positive culture and employee well-being. We offer fully remote work, flexible schedules, and generous vacation policy along with affordable health coverage, stock options, annual bonuses, and more! The Senior Scientist will lead the mathematical representation of core areas within the DILIsym Services areas of expertise, some core areas include mitochondrial dysfunction, bile acid transport, immune response/cell death, biomarkers, pharmacokinetics, lipotoxicity, NAFLD and NASH, IPF, and kidney injury. Department: Research and Development Internal Grade: 13 Direct Reports: No Status: Exempt Location: Remote Job Responsibilities: * Design, write, test, and use computer code to build and maintain the sub-model(s) related to a given core area (e.g. DILIsym, NAFLDsym, IPFsym, RENAsym, RADAsym) * Represent compounds and drugs in DILIsym, including translating laboratory data into model parameters * Contribute to the activities required for successful completion of all goals, including those of the various development efforts and the DILI-sim Initiative consortium * Combine technical and project management work, including components such as systems pharmacology modeling, software code development, and maintenance in MATLAB or other designated software environments * Develop plans to complete all tasks and provide all deliverables within a time frame consistent with the services agreement signed with the sponsor * Schedule the necessary meetings including internal and external collaborators * Travel to sponsor locations to participate in key milestone meetings as required * Exerts leadership in the area of report and presentation preparation, which are critical final deliverables for all projects * Manage and participate in preparation and review of all joint manuscripts between the DILIsym Services and the sponsor * Ensure the effort expended for a given project remains consistent with the resources allocated for the project per the signed contract * Publish work in scientific journals, with minimal review required by their supervisor, including documentation preparation, text development, figure development, and correspondence with editors and peer reviewers * Oversee and supervise the technical work of others and mentor less experienced scientists * Train others on QSP/QST and the various DSS platforms * Other duties as assigned Qualifications: * 10+ years of QSP/QST modeling experience * General knowledge of pharmacology, biology, biochemistry, lipid biochemistry, immunology, * and/or toxicology * Proficiency in SimBiology, MATLAB, Python, or R * Experience with GastroPlus™ or DILIsym preferred * PK modeling, PKPD modeling, and systems pharmacology modeling * Proficiency in mathematics * Understand development process and how to apply modeling and simulation for maximum impact * Strong critical thinking and problem solving skills * Strong verbal and written communication skills * Maintain a positive attitude while interacting with colleagues and clients * Must be able to multitask and have great organizational skills * Self-motivated with ability to work with minimal supervision * Minimal travel required up to 10% Education: * Master’s degree in pharmaceutical science, biomedical engineering, or related life sciences field * PhD in pharmaceutical science, biomedical engineering, or related life sciences field preferred Find out more about how amazing it is to work at Simulations Plus by visiting www.simulations-plus.com/career-center [http://www.simulations-plus.com/career-center] and apply today!

Responsibilities

The Senior Scientist will lead the mathematical representation of core areas within the DILIsym Services, including tasks such as designing and maintaining sub-models and translating laboratory data into model parameters. They will also manage project deliverables and mentor less experienced scientists.