Function
Discovery & Pre-Clinical/Clinical Development
Sub function
Biological Research
Category
Senior Principal Scientist, Biological Research (ST8)
Location
Spring House / United States of America
Date posted
Jun 16 2025
Requisition number
2506232469W
Work pattern
Fully Onsite
This job posting is anticipated to close on Jun 24 2025. We may however extend this time period, in which case the posting will remain available on www.careers.jnj.com to accept additional applications.
Description
At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com

WE ARE SEARCHING FOR THE BEST TALENT FOR SR. PRINCIPAL SCIENTIST, CELLULAR & MECHANISTIC PHARMACOLOGY TO BE IN SPRING HOUSE, PA.

Purpose: The Discovery Technologies & Molecular Pharmacology (DTMP) team within Therapeutics Discovery contributes to the progression of drug discovery projects from target identification to clinical development. Join our team! We’re looking for a talented scientist with an immunology background, deep expertise in disease biology and cellular pharmacology, and a passion for finding innovative therapeutics to treat diseases with high unmet medical need.

EDUCATION:

• Minimum of Ph. D. in Immunology, cell biology or equivalent with post-doctoral experience and a minimum of 10 years of experience developing and applying novel cellular assays in a pharmaceutical industry/biotech setting, is required.

• Lead development of innovative cell-based assays for immunology-focused projects to identify and evaluate targets, and to progress hits and lead molecules.
• Act as a key liaison between DTMP and program teams, driving project strategy and execution, in partnership with cross-functional colleagues.
• Lead efforts to combine translational and mechanistic assays with biosignature approaches and novel AI/ML methods to reveal new biology and pharmacology.
• Manage and mentor lab scientists and contribute to the cellular and mechanistic pharmacology portfolio.
• Analyze and present data at program team meetings, in-house seminars, leadership meetings and external scientific conferences, and publish research in high-quality journals.