WORKING WITH US

Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us .

OVERVIEW

We are seeking an experienced and motivated Research Scientist with at least 5 years of laboratory research experience in the pharmaceutical, biotechnology, or academic sectors. The successful candidate will play a key role in our Lawrenceville, NJ Discovery Toxicology team at Bristol Myers Squibb, contributing to early drug discovery through in vitro or ex vivo investigative toxicology studies focused on cardiovascular and nervous system safety assessment, mechanistic investigations, and early biomarker identification.
This position will work within a dynamic, multidisciplinary, matrixed team environment, leveraging advanced cellular models-including stem-cell derived cardiomyocytes and neurons, organoids, and microphysiological systems. Hands-on expertise with functional in vitro assays such as electrophysiology (patch-clamp, multielectrode array), dynamic calcium or fluorescence imaging, and exposure to new approach methodologies is required.
The ideal candidate demonstrates a collaborative mindset, rigorous scientific approach, and outstanding communication and technical skills.

Key Responsibilities

• Design, execute, and analyze in vitro studies evaluating cardiovascular or nervous system toxicity for early drug discovery targets and compounds.
• Develop, optimize, and apply functional assays-electrophysiological, contractility, impedance, imaging, metabolic-using advanced cellular and tissue models for mechanistic safety investigation and biomarker discovery.
• Characterize on-target or off-target liabilities and pharmacodynamic endpoints in in vitro cellular or ex vivo tissue model systems.
• Perform multifaceted data analysis using specialized software, including analysis of large data sets and/or use of statistical programming.
• Author internal scientific reports, prepare manuscripts for publication, and present at internal/external meetings and conferences.
• Ensure excellent documentation and data recording in compliance with BMS standards and policies.
• Foster scientific excellence, open communication, and creativity to maximize team productivity.

Required Qualifications

• PhD+3 years, MA/MS+5 years, BA/BS+7 years research experience (academic, biotech, pharma) in physiology, pharmacology, toxicology, or a closely related field
• Proven expertise performing and interpreting functional cellular/tissue assays: patch-clamp (manual or automated) electrophsyiology, multielectrode array electrophysiology, contractility, impedance, fluorescence imaging.
• Practical experience with organoids, microphysiological systems or other new approach methodologies
• Practical experience with cell culture, including maintenance of cell lines, primary cell isolation and culture, and stem-cell derived models (cardiomyocytes, neurons).
• Skilled in data analysis, statistics, presentation, and scientific writing.
• Technically adept, logical, and proactive problem-solver.
• Effective communicator, capable of collaborating across teams and organizational levels.

Preferred Qualifications

• Experience with advanced imaging systems (confocal microscopy, image analysis software).
• Proficiency in molecular biology techniques: siRNA, PCR.
• Familiarity with in silico/computational toxicology approaches.
• Experience with Manual and/or automated patch clamp (e.g. Patchliner, Port -a-Patch).
• Experience with cell isolation or tissue harvesting for use in functional in vitro/ex vivo assays (electrically excitable cells, smooth muscle, perfused organs).

• Design, execute, and analyze in vitro studies evaluating cardiovascular or nervous system toxicity for early drug discovery targets and compounds.
• Develop, optimize, and apply functional assays-electrophysiological, contractility, impedance, imaging, metabolic-using advanced cellular and tissue models for mechanistic safety investigation and biomarker discovery.
• Characterize on-target or off-target liabilities and pharmacodynamic endpoints in in vitro cellular or ex vivo tissue model systems.
• Perform multifaceted data analysis using specialized software, including analysis of large data sets and/or use of statistical programming.
• Author internal scientific reports, prepare manuscripts for publication, and present at internal/external meetings and conferences.
• Ensure excellent documentation and data recording in compliance with BMS standards and policies.
• Foster scientific excellence, open communication, and creativity to maximize team productivity