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SRA/ARS - ADC Bioconjugation at o2h Group
, gujarat, India -
Full Time

Start Date

Immediate

Expiry Date

08 Feb, 26

Salary

0.0

Posted On

10 Nov, 25

Experience

2 year(s) or above

Remote Job

Yes

Telecommute

Yes

Sponsor Visa

No

Skills

Bioconjugation, Antibody Conjugation, Protein Chemistry, Analytical Characterisation, Organic Chemistry, Medicinal Chemistry, Attention to Detail, Interpersonal Skills, Collaboration, Time Management, Integrity, Communication Skills, Chromatography, Chemical Conjugation, Drug-to-Antibody Ratio, Cytotoxic Payloads, Linkers

Industry

Biotechnology Research

Description
Design, synthesise, and optimise linkers and cytotoxic payloads for ADCs. Determine and optimise Drug-to-Antibody Ratio (DAR) and conjugation efficiency. Characterise ADCs for purity, stability, and functionality using LC-MS/MS, HPLC, SEC, CE, HIC, SDS-PAGE and other analytical techniques. Perform antibody conjugation to chemical linkers using standard bioconjugation chemistries (e.g., thiol-maleimide, NHS ester, click chemistry). Purify antibody-linker conjugates using chromatography techniques (SEC, HIC, affinity purification). Hands-on experience with protein chemistry, Protein expression, chemical conjugation, especially antibody conjugation and modification. Strong background in organic/medicinal chemistry/Biochemistry and bioconjugation techniques. Hands-on experience with antibody–drug conjugation (cysteine, lysine, enzymatic). Proficiency in analytical characterisation methods: LC-MS/MS, HPLC, SEC, CE, UV-Vis spectroscopy. Must have good manual dexterity and demonstrate careful attention to detail. Interpersonal skills to interact effectively with people in other departments. Work collaboratively with others and be able to adapt to various work assignments. Must be able to prioritize and organize work responsibilities in order to meet deadlines. Must possess a great deal of integrity to maintain confidentiality. Good oral and written (English) communication skills.
Responsibilities
Design, synthesize, and optimize linkers and cytotoxic payloads for antibody-drug conjugates (ADCs). Characterize ADCs for purity, stability, and functionality using various analytical techniques.